CT-2A cell line is a valuable model for therapeutic research on brain malignancies. Tumors are WT for p53, recapitulating features of human high-grade glioma.
The CT-2A cell line is derived from a sub-cutaneous, non-metastatic murine glioma (astrocytoma). The originating tumor was classified as poorly differentiated with high vascularity and malignancy (2). CT-2A cells are marked by high levels of complex gangliosides and low distribution of the anti...