CT-2A cell line is a valuable model for therapeutic research on brain malignancies. Tumors are WT for p53, recapitulating features of human high-grade glioma.
CT-2A was generated from a malignant astrocytoma formed via implantation of the carcinogen 20-methylcholanthrene in the cerebrum of a C57BL/6J mouse (7). The tumor was maintained through serial intracranial transplants prior to cell line isolation. ...
英文名称:CT-2A Mouse Glioma Cell Line 欣博盛生物科技有限公司 联系电话:4006-800-892 电子邮件:info@neobioscience.com CB指数:58 网址:www.nbs-bio.com 相关信息:产品目录(6207) 用户评价 英文名称:CT-2A Mouse Glioma Cell Line Tag: CT-2A Mouse Glioma Cell Line 主页...
Evaluation of 18F-Fluciclovine PET/CT in Mouse Models of Glioma and Radiation Treatment Effect242177 Introduction: High-grade gliomas are a significant diagnostic and therapeutic challenge in oncology, resulting in severe morbidity and mortality for patients. Despite advances in diagnostic modalities, ...
The cell mixtures were prepared using the TaqMan™ Gene Expression Cells-to-CT™ and assayed for a mouse-specific and human-specific gene. Comparative data were generated in the same manner with RNA purified by traditional methodology. The data show that RNA from as few as 10 mouse cells ...
Glioma is one of the most prevalent and deadly tumors, accounting for more than 70% of all primary malignant brain tumors.1 Numerous genomic alterations associated with glioma heterogeneity contrib...
This present study is the first to employ in-situ proteomic and cytokine analysis on a brain tumor mouse model of orthotopically xenografted human U251 glioma cell transfectants stably co-expressing CTRP8 and RXFP1. U251-CTRP8/RXFP1 glioma were found to be highly aggressive and presented ...
Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol 2002; 22: 5296–5307. Article CAS Google Scholar Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F et al. Coordinated histone modifications mediated by a Ct...
Strikingly, these effects were not dependent on ablation of TAM in GBM, as this cell population was protected by glioma-secreted survival factors such as IFNγ and GM-CSF. Instead, CSF-1R blockade caused the downregulation of a set of protumor genes, including Arg1 and Mrc1 [106]. These ...
glioma, lung, ovarian, pancreatic, and renal cell3,4,5,6,7, and this dysregulation is often associated with a more aggressive phenotype and accordingly worse survival of the cancer patients8. This scenario makes the EGFR family an ideal target to be exploited for cancer therapeutics9,10,11....