GliomaIn this chapter, we describe the evolution of experimental models for brain tumors. Model systems were established as early as the 1920s, when chemical carcinogenesis was used to elicit malignant neoplasms in various tissues or organs, including the central nervous system. A more systematic ...
Table 2 Trends in xenograft and allograft mouse models of glioma Full size table A library of orthotopic glioblastoma xenograft models using surgical samples of glioblastoma patients has been established. These patient-derived glioblastoma xenograft (PDX) tumors recapitulated histopathological properties and ...
In glioma, autocrine and paracrine expression of PDGF-A leads to chronic PDGFR signaling14,15,16. Therefore, to simulate this clinically relevant observation in P1 and P2 mice, we performed intracranial stereotactic injections of a lentivirus engineered to express an inducible (doxycycline, DOX) huma...
Establishment of patient-derived cancer xenografts in immunodeficient NOG mice Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2Rγnull mouse Incidence of spontaneous lymphomas ...
medulloblastoma (MB) and high-grade glioma has stimulated an urgent need for animal models that will not only replicate the biology of these tumors, but al... Q Shu,KK Wong,JM Su,... - 《Stem Cells》 被引量: 0发表: 2008年 Genetic ablation of Gpr37l1 delays tumor occurrence in Ptch1...
PD-L1 plays a key regulatory role, and highly expressed in various tumors, such as glioma, ovarian cancer, melanoma and lung cancer etc. [7]. And patients with tumors overexpressing PD-L1 normally correlates with the size of tumor, the number of lymph node, the grades of tumor and the ...
Cerebrovascular changes occur in Alzheimer’s disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGR
Establishment of patient-derived cancer xenografts in immunodeficient NOG mice Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2Rγnull mouse Incidence of spontaneous lymphomas ...
Our mouse models have shown great advantages such as high safety, easy operation, low price, and real-time quantitative monitoring. In our labs, U251 glioma cells with red fluorescence were inoculated into the brains of green fluorescent naked mice for dynamic in vivo fluorescence imaging. At...
IDH1-R132H results in gain of an alternative enzymatic function producing the metabolite 2-hydroxglutarate (2HG) and alterations in histone methylation patterns. Animal models are critical to study and understand disease progression and pathogenesis; therefore we developed an in vivo model of young ...