PPARγ plays a crucial role in terminal differentiation of MMP9+ TAMs In hepatocellular carcinoma (HCC), with knockdown of corresponding gene or treatment with PPARγ inhibitors resulting in a significant decre
M. et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1, 269–277 (2002). Article CAS PubMed Google Scholar Friedmann-Morvinski, D. & Verma, I. M. ...
This mutation results in Lys27Met (K27 M) substitution on the H3 N-terminal tail in up to 80% of tumors, and is associated with as a more aggressive clinical course and poorer response to therapy. This mutation at a critical H3 transcriptional regulatory residue alters chro- matin structure...
M. et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1, 269–277 (2002) Article CAS Google Scholar Rietze, R. L. & Reynolds, B. A. Neural stem cell ...
The FGFR family plays an important role in cell growth, differentiation, and angiogenesis, and its activation usually contributes to carcinogenic events [54]. The oncogenic activities of the FGFR-TACC fusion protein are greater than the sum of its parts when introduced into astrocytes or stereo...
(particularly oligodendrocytes and astrocytes; ependymal cells) originates during the differentiation process. The glioma originates from the direct transformation of neural stem cells or glial progenitor cells. Glial tumorigenesis is driven by upregulation or downregulation of various growth factor receptor...
MiR-491 has reference significance for predicting the degree of differentiation and metastasis of glioma(Hao et al., 2024). Secondly, miRNAs can participate in tumor formation from multiple direction such as angiogenesis, tumor proliferation, invasion and metastasis, apoptosis and autophagy. Malignant ...
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, Defrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, Depinho RA (2002) Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural...
Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells. Cancer Sci. 2011;102(7):1350–7. Article CAS PubMed Google Scholar Santra M, Santra S, Roberts C, Zhang RL, Chopp M. Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion. ...
The lysyl oxidase (LOX) family is closely related to the progression of glioma. To ensure the clinical significance of LOX family in glioma, The Cancer Genome Atlas (TCGA) database was mined and the analysis indicated that higher LOXL1 expression was cor