16. Mooney, P. Optimization of image collection for cellular electron microscopy.Methods in cell biology79, 661-719 (2007). 17. Suloway, C. et al. Automated molecular microscopy: the new Leginon system.Journal of structural biology151, 41-60 (2005). 18. McMullan, G., Faruqi, A. & H...
Cryo-EM in molecular and cellular biologyCRYOELECTRON MICROSCOPYRESOLUTIONREFINEMENTIMPLEMENTATIONSAMPLESThis review summarizes the current state of methods and results achievable by cryo-electron microscopy (cryo-EM) imaging for molecular, cell, and structural biologists who wish to understand what is ...
Departments of Medicine (Division of Gastroenterology and Hepatology) and Microbiology & Immunology, Stanford School of Medicine, Stanford, CA, USA Rachel J. Hagey, Edward A. Pham, Claire Bernardin-Souibgui & Jeffrey S. Glenn Department of Molecular and Cellular Biology, Harvard University, Cambridg...
Cryoelectron microscopy Molecular biology This article is cited by A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility Juepu Zhou Ruolin Mao Lixia Zhu Journal of Ovarian Research (2024) Pannexins in the musculoskeletal system: new targets for development...
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The second tubulin structure is in a curved conformation, bound to the cellular depolymerizer RB3 (a homologue of stathmin/Op18) and microtubule-destabilizing ligands (colchicine, podophyllotoxin, or vinblastine) (Gigant et al., 2000, Gigant et al., 2005, Ravelli et al., 2004). There is ...
The graph above is a comparison between the resolution and molecule size for published single-particle cryo-EM structures. Gatan's direct detectors have been employed in all the structures which define the high-resolution frontier across a range of molecular sizes. Advantages of single-particle cryo...
Read more about the rise of structural virology in our new eBook, out now >> // Georgios Skiniotis is a Professor of Structural Biology, and of Molecular and Cellular Physiology at Stanford University, and, by courtesy, of Photon Science at SLAC National Accelerator Laboratory. He is also ...
With the paradigm shift to structure determination of highly complex endogenous macromolecular complexes ex vivo and in situ structural biology, there are an increasing number of structures of native complexes. These complexes often contain unidentified proteins, related to different cellular states or ...
and characterized, the molecular basis is still an area of active investigation. By using structural biology, researchers have begun to unravel the molecular changes that lead to neurological disorder – these efforts, in turn, drive the development of therapeutics that can slow or stop the course...