Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature. 2017;548:352-355.Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D et a
De novo structure modeling for nucleic acids in cryo-EM maps using deep learning. Nat. Methods (2023). Mukherjee, S. & Zhang, Y. MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming. Nucleic Acids Res. 37, e83 (2009). ...
Rational design leveraging routine, high resolution protein structure determination is driving the discovery and development of diverse biologic and small molecule therapies. Cryo-EM delivers rapid epitope mapping on the atomic scale for antibody therapeutics and immune response profilin...
The Glacios 2 Cryo-TEM is a powerful tool applicable for single particle, MicroED and cryo-ET applications that can help answer some of the most challenging research and drug discovery questions. Explore applications Protein structure determination with cryo-EM ...
之后会更新学习笔记以及CryoEM Protein Structure 3D reconstruction 以及对论文的学习 Exploring generative atomic models in cryo-EM reconstructionarxiv.org/abs/2107.01331 Reconstructing continuous distributions of 3D protein structure from cryo-EM imagesarxiv.org/abs/1909.05215 CryoDRGN: reconstruction of...
Cryo-EM is revolutionizing structural biology due to its unique capability of determining the structures of large protein complexes and assemblies. The atomic-resolution structure determination for proteins enabled by cryogenic electron microscopy (cryo-EM) [3], allows us to understand the complex bio-...
and Cube Biotech, a pioneer in membrane protein production and purification technologies, have announced a partnership agreement to develop a streamlined, cryo-EM enabled gene-to-structure workflow, to ultimately accelerate medicinal chemistry analysis and revolutionize the field of membrane protein research...
Structure based rational drug design Cryo-EM can enable you to visualize molecules across a range of sizes and can help you obtain time-critical insights for your drug discovery projects. Learn more Cookie设置 我们及我们的关联方等通过运用Cookie等技术来为您提供您感兴趣的网站定制内容、识别访问者、...
“The biggest advantage I see with cryo-EM…is that you need very little protein, so you are able to make reasonable amount in mammalian cells and without the need of crystals.” Dr. Vinothkumar K.R, NCBS-TIFR, India 0:00 Dr. Paolo Swuec On Cryo-EM Structure of Cardiac Amyloid ...
Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genes doi:10.1038/s41467-025-60116-6Biological SciencesBiochemistry and Cell BiologyBacterial mating, or conjugation, was discovered nearly 80 years ago as a process transferring genes...