Cross-Electrophile CouplingCooperative Catalysisgem-Difluoroalkenesgem-Difluorovinyl TosylatesPhenol DerivativesA dual nickel‐/palladium‐catalyzed direct gem‐difluorovinylation of readily available aryl/vinyl triflates with substituted gem‐difluorovinyl tosylates is presented. This protocol affords various ...
A critical overview of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity. Recent synthetic advances and mechanistic studies have shed light on four possible methods for overcoming this cha...
Owing to the broad availability of alkyl halides, their direct cross-coupling—commonly known as cross-electrophile coupling—provides a promising route towards this objective3,4,5. Such transformations circumvent the preparation of carbon nucleophiles used in traditional cross-coupling reactions, as well...
Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling. A strategy for cross-electrophile coupling has been developed via the merger of photoredox and transition metal catalysis. In this report, we demonstrate the use of commercially ...
Fig. 1: Design and applications of the cross-electrophile coupling of carboxylic acids with aldehydes. A Elusive cross-electrophile coupling between carboxylic acids and aldehydes. B Fast and scalable activation of aldehydes. C Our strategy: visible-light promoted coupling of activated carboxylic acids...
cross‐couplingsynthetic methodsreductionMatthew J. GoldfogelUniversity of Wisconsin Department of Chemistry 1101 University Avenue Madison WI 53706 USALiangbin HuangUniversity of Wisconsin Department of Chemistry 1101 University Avenue Madison WI 53706 USADaniel J. Weix...
Cross-electrophile coupling of aryl halides with alkyl halides has thus far been primarily conducted with stoichiometric metallic reductants in amide solvents. This report demonstrates that the use of tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables the use of non-amide solvents,...
A high-yielding cross-electrophile coupling of aryl or hetaryl halides with functionalized alkyl halides is examined.doi:10.1002/chin.201652170Anka-Lufford, Lukiana L.Huihui, Kierra M. M.Gower, Nicholas J.Ackerman, Laura K. G.Weix, Daniel J....
Enantioselective C(sp3)-C(sp3) Reductive Cross-Electrophile Coupling of Unactivated Alkyl Halides with α‑Chloroboronates via Dual Nickel/Photoredox Catalysis. J. Am. Chem. Soc.2023, https://doi.org/10.1021/jacs.2c1322...
1 | Cross-electrophile C − Si coupling reactions. a TM-catalyzed XEC of chlorosilanes. b This work: XEC of alkynyl sulfides with chlorosilanes. appropriate alkynyl electrophile and metal catalyst was the key to achieve the XEC between alkynyl electrophiles and chlorosilanes. Easily synthesized ...