Cross-Electrophile CouplingCooperative Catalysisgem-Difluoroalkenesgem-Difluorovinyl TosylatesPhenol DerivativesA dual nickel‐/palladium‐catalyzed direct gem‐difluorovinylation of readily available aryl/vinyl triflates with substituted gem‐difluorovinyl tosylates is presented. This protocol affords various ...
Cross-electrophile coupling of aryl halides with alkyl halides has thus far been primarily conducted with stoichiometric metallic reductants in amide solvents. This report demonstrates that the use of tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables the use of non-amide solvents,...
The catalytic asymmetric construction of Csp3–Csp3bonds remains one of the foremost challenges in organic synthesis1. Metal-catalysed cross-electrophile couplings (XECs) have emerged as a powerful tool for C–C bond formation2,3,4,5. However, coupling two distinct Csp3electrophiles with high ...
cross‐couplingsynthetic methodsreductionMatthew J. GoldfogelUniversity of Wisconsin Department of Chemistry 1101 University Avenue Madison WI 53706 USALiangbin HuangUniversity of Wisconsin Department of Chemistry 1101 University Avenue Madison WI 53706 USADaniel J. Weix...
While there have been laudable strides made within the domain of C(sp3)−C(sp3) cross-coupling, contemporary methodologies are oftentimes plagued by several pragmatic limitations5,6. They typically necessitate sizable excesses of one coupling partner and frequently hinge upon non-abundant starting ...
Enantioselective C(sp3)-C(sp3) Reductive Cross-Electrophile Coupling of Unactivated Alkyl Halides with α‑Chloroboronates via Dual Nickel/Photoredox Catalysis. J. Am. Chem. Soc.2023, https://doi.org/10.1021/jacs.2c1322...
A nickel-catalyzedcross-electrophile coupling reaction betweenbenzyl alcohols and aryl halides has been developed using a homolyticC–O bond cleavage protocol that has recently been established.The treatment of a benzyl alcohol and aryl halide with a nickel catalystand low-valent titanium reagent generat...
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Herein, we report a mild nickel-catalyzed cross-electrophile coupling of α-hydroxy ester and ketone-derived oxalates with vinyl triflates via C–O/C–O bond cleavage (Scheme 1c). This protocol features good coupling efficiency and broad substrate scope, and is therefore a useful complementary ...
摘要: A nickel-catalyzedcross-electrophile coupling reaction between(hetero)aryl bromides and 2,2-difluorovinyl tosylate is presented.This protocol provides facile incorporation of the ) cross-electrophile coupling reactions.关键词: DFT studies 2,2-difluorovinyl tosylate gem-difluoroalkenes cross-...