In this mini‐review, we have systematically summarized the most recent advances in electroreductive cross‐electrophile coupling (eXEC) reactions during the last decade. Our focus has been on readily available electrophiles, including aryl and alkyl organic (pseudo)halides, as well ...
A critical overview of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity. Recent synthetic advances and mechanistic studies have shed light on four possible methods for overcoming this cha...
The catalytic asymmetric construction of Csp3–Csp3bonds remains one of the foremost challenges in organic synthesis1. Metal-catalysed cross-electrophile couplings (XECs) have emerged as a powerful tool for C–C bond formation2,3,4,5. However, coupling two distinct Csp3electrophiles with high ...
Fig. 1: Design and applications of the cross-electrophile coupling of carboxylic acids with aldehydes. A Elusive cross-electrophile coupling between carboxylic acids and aldehydes. B Fast and scalable activation of aldehydes. C Our strategy: visible-light promoted coupling of activated carboxylic acids...
cross‐couplingsynthetic methodsreductionMatthew J. GoldfogelUniversity of Wisconsin Department of Chemistry 1101 University Avenue Madison WI 53706 USALiangbin HuangUniversity of Wisconsin Department of Chemistry 1101 University Avenue Madison WI 53706 USADaniel J. Weix...
Enantioselective C(sp3)-C(sp3) Reductive Cross-Electrophile Coupling of Unactivated Alkyl Halides with α‑Chloroboronates via Dual Nickel/Photoredox Catalysis. J. Am. Chem. Soc.2023, https://doi.org/10.1021/jacs.2c1322...
Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy Herein, we describe the reductive nickel-catalyzed cross-electrophile coupling of unactivated alkyl bromides with symmetrical alkyl- and aryltetrasulfides to ... F Wang,Y Chen,W Rao,... - 《Nature Communi...
Cross-electrophile coupling of aryl halides with alkyl halides has thus far been primarily conducted with stoichiometric metallic reductants in amide solvents. This report demonstrates that the use of tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables the use of non-amide solvents,...
Cross-Electrophile Coupling of Benzyl Halides and Disulfides Catalyzed by Iron 2024, Journal of the American Chemical Society Advances in Cross-Coupling Reactions Catalyzed by Aromatic Pincer Complexes Based on Earth-Abundant 3d Metals (Mn, Fe, Co, Ni, Cu) 2024, Catalysts Synthesis, Crystal Structu...
Owing to the broad availability of alkyl halides, their direct cross-coupling—commonly known as cross-electrophile coupling—provides a promising route towards this objective3,4,5. Such transformations circumvent the preparation of carbon nucleophiles used in traditional cross-coupling reactions, as well...