This protocol affords various diaryldifluoroalkene, arylalkyldifluoroalkene and 1,1‐difluoro‐2‐substituted‐1,3‐dienes under mild reaction conditions with excellent functional group compatibility, and provides a potential pathway to the late‐stage functionalization of complex bioactive molecules....
B. et al. Nickel-catalyzed alkyl−alkyl cross-electrophile coupling reaction of 1,3-dimesylates for the synthesis of alkylcyclopropanes. J. Am. Chem. Soc. 142, 5017–5023 (2020). Article CAS PubMed PubMed Central Google Scholar Qian, X., Auffrant, A., Felouat, A. & Gosmini, C....
Although various synthetic routes have been delineated, an intuitive retrosynthetic strategy entailing a cross-coupling reaction between a benzyl electrophile and α-amino nucleophile has remained underrepresented44,45,46. We posit that the advanced cross-electrophile coupling between NHPI esters and ...
A nickel-catalyzedcross-electrophile coupling reaction betweenbenzyl alcohols and aryl halides has been developed using a homolyticC–O bond cleavage protocol that has recently been established.The treatment of a benzyl alcohol and aryl halide with a nickel catalystand low-valent titanium reagent generat...
When 1 equiv of ZnI2 was added together with Mn, the reaction generated the product 3a in 67% yield (entry 8). This indicated that Zn not only acted as reductant, but also the in-situ formed zinc salt as a thiophilic reagent to decrease the inhibition of the leaving sulfide part ...
We report a general and practical strategy to address this problem in the reaction between reactive and unreactive electrophiles by a combination of nickel and Lewis acid catalysis. This strategy is used for the coupling of aryl halides with allylic alcohols to form linear allylarenes selectively....
coligand. The reaction was tolerant of protic substrates, and C− B bonds were not reactive under these conditions. Not only unhindered primary, but secondary and neopentyl alkyl halides could also be coupled with aryl iodides (Scheme 2). Figure 1. Cross-electrophile coupling (bottom) versus ...
A novel method for the preparation of substituted allyl aziridines by reaction of 伪-halo with allylic zinc reagents in mild conditions is reported in this paper. The present method complements the existing synthetic methods due to some ... S Zheng,S Zhang - 《Rsc Advances》 被引量: 0发表...
Kumada-Tamao-Corriu coupling reaction catalyzed by transition-metal has been widely used in organic synthesis. Organic halides are mostly used as electrophiles in this reaction. Compared with organic halides, O-based electrophiles are less explored. In this review, we summarized the Kumada-Tamao-Cor...
s and Electrophiles ChemInform Abstract: Ytterbium Metal-Promoted Novel Cross-Coupling Reaction Between Diaryl Ketones and ElectrophilesChemInform Abstract: Ytterbium Metal-Promoted Novel Cross-Coupling Reaction Between Diaryl Ketones and Electrophilesfluorene derivatives...