Transition metal-catalyzed cross-electrophile coupling (XEC) is a powerful tool for forging C(sp)鈥揅(sp) bonds in biaryl molecules from abundant aromatic halides. While the synthesis of unsymmetrical biaryl compounds through multimetallic XEC is of high synthetic value, the selective XEC of two ...
In recent years, nickel-mediated cross-electrophile (XEC) coupling has emerged as a potent strategy for constructing C(sp3)−C(sp3) bonds, utilizing various native and bench-stable aliphatic coupling entities, thus circumventing the use of moisture-sensitive organometallic species8,9,10,11,12,13...
A critical overview of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity. Recent synthetic advances and mechanistic studies have shed light on four possible methods for overcoming this cha...
(XECs) have emerged as a powerful tool for C–C bond formation2,3,4,5. However, coupling two distinct Csp3electrophiles with high cross-selectivity and stereoselectivity continues as an unmet challenge. Here we report a highly chemoselective and enantioselective Csp3–Csp3XEC between alkyl ...
1 | Cross-electrophile C − Si coupling reactions. a TM-catalyzed XEC of chlorosilanes. b This work: XEC of alkynyl sulfides with chlorosilanes. appropriate alkynyl electrophile and metal catalyst was the key to achieve the XEC between alkynyl electrophiles and chlorosilanes. Easily synthesized ...
and the activation of chlorosilanes occurred via an SN2 process instead of a radical pathway.#Transition-metal catalyzed cross-electrophile coupling (XEC) is a powerful tool for the construction of molecules but XEC between carbon electrophile and chlorosilanes to access organosilicon compounds remains ...
Nickel-catalysed cross-electrophile coupling (XEC) is a useful reaction in synthetic organic chemistry. Now, a nickel-catalysed electrochemical XEC reaction mediated by dynamic ligand exchange enables the formation of a C(sp2)–C(sp3) bond between tertiary alkyl bromides and aryl (pseudo)halides....
Owing to the broad availability of alkyl halides, their direct cross coupling-commonly known as cross-electrophile-coupling (XEC)-provides a promising route toward this objective 3-5 . Such transformations circumvent the preparation of carbon nucleophiles used in traditional cross-coupling reactions as ...
and the activation of chlorosilanes occurred via an SN2 process instead of a radical pathway.#Transition-metal catalyzed cross-electrophile coupling (XEC) is a powerful tool for the construction of molecules but XEC between carbon electrophile and chlorosilanes to access organosilicon compounds remains ...
Zinc and manganese are widely used as reductants in synthetic methods, such as nickel-catalysed cross-electrophile coupling (XEC) reactions, but their redox potentials are unknown in organic solvents. Here we show how open-circuit potential measurements may be used to determine the thermodynamic ...