文献解读｜结直肠癌（CRC）类器官-基质生物库反映细胞异质性 今天给大家分享一篇构建肿瘤类器官-基质生物库进行研究的文章，来自德国Georg-Speyer-Haus实验室的Henner F Farin等在2023年5月5日发表在Cancer Discovery（28.2/IF）上题为“Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of...
ORGANOIDSOrganoids derived from epithelial tumors have recently been utilized as a preclinical model in basic and translational studies. This model is considered to represent the original tumor in terms of 3D structure, genetic and cellular heterogeneity, but not tumor microenvironment. In this study,...
3dGRO® Human CRC Organoids (ISO34); Synonyms: organoid, PDO, cancer organoid, tumor organoid, 3d cell culture, colorectal cancer; find Sigma-Aldrich-SCC500 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldri
今天给大家分享一篇构建肿瘤类器官-基质生物库进行研究的文章,来自德国Georg-Speyer-Haus实验室的Henner F Farin等在2023年5月5日发表在Cancer Discovery(28.2/IF)上题为“Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses”的文章。文章主要内容是构建结直...
今天给大家分享一篇构建肿瘤类器官-基质生物库进行研究的文章,来自德国Georg-Speyer-Haus实验室的Henner F Farin等在2023年5月5日发表在Cancer Discovery(28.2/IF)上题为“Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses”的文章。文章主要内容是构建结直...
Mao Y, Wang W, Yang J, Zhou X, Lu Y, Gao J, Wang X, Wen L, Fu W, Tang F. Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids. Protein Cell. 2023 Jun 22:pwad038. doi: 10.1093/procel/pwad038. Epub ahead of print. PMID: 37345888.来源：...
Mao Y, Wang W, Yang J, Zhou X, Lu Y, Gao J, Wang X, Wen L, Fu W, Tang F. Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids. Protein Cell. 2023 Jun 22:pwad038. doi: 10.1093/procel/pwad038. Epub ahead of print. PMID: 37345888. ...
该研究团队使用伯桢生物的结直肠癌(无血清)类器官培养试剂盒Colorectal Cancer Organoid Kit(Serum-free)(K2103-CR)成功构建了结直肠癌类器官并完成了全文类器官相关实验。基于类器官模型,研究团队发现POU6F2-AS1敲低会抑制结直肠癌PDO的形成,而POU6F2-AS1过表达则促进PDO的形成,与前期临床和细胞数据一致。在本研...
Organoids derived from epithelial tumors have recently been utilized as a preclinical model in basic and translational studies. This model is considered to represent the original tumor in terms of 3D structure, genetic and cellular heterogeneity, but not tumor microenvironment. In this study, we esta...
2024年9月,日内瓦大学Patrycja Nowak-Sliwinska教授团队在期刊《Journal of Experimental and Clinical Cancer Research》(IF:11.4)在线发表题为:Challenges in validation of combination treatment strategies for CRC using patient-derived organoids 的高水平综述论文。