can retain the original tumor heterogeneity and are commonly used to mimic the cancer microenvironment when co-cultured with fibroblasts and immune cells; therefore, considerable effort has been made recently to promote the use of this new technology from basic research to clinical studies in tumors....
The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues for the development of novel, more physiological human cancer models. Such preclinical models are essential for more efficient translation of basic cancer
Organoids in cancer research Nature Reviews Cancer(IF72.5)Pub Date : 2018-04-24, DOI:10.1038/s41568-018-0007-6 Jarno Drost , Hans Clevers The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues for the development of novel, more physiological hum...
3D Organoids Lead the Way for Personalized Cancer Therapy As oncology researchers continue to find immense value in the applications of3D organoidsfor their work, one area stands to gain a great deal from the advancements of thesein vivo-like environments and cu...
Supporting Cancer Cells in Micro-Environments The research also showed that the organoids provide a micro-environment that can accept and support the survival of cells from patients with blood malignancies, including multiple myeloma cells, which are notoriously difficult to maintain outside the human...
et al. Mouse and human urothelial cancer organoids: a tool for bladder cancer research. Proc. Natl Acad. Sci. USA 116, 4567–4574 (2019). Article CAS PubMed PubMed Central Google Scholar Kretzschmar, K. & Clevers, H. Organoids: modeling development and the stem cell niche in a dish...
Orakl developing in vitro diagnostic test using organoids for colorectal cancer March 28, 2023 ByBernard Banga The Gustave Roussy cancer center, specializing in cancer treatment, and its technology transfer subsidiary Gustave Roussy Transfert, reported the creation of startup Orakl SA, which develops...
Significant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids have evolved into complex structures and are increasingly recogn
K. Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer. Cell. Mol. Gastroenterol. ... S Prasad,A Chandra,E Lonardo,... - 《Cancer Research》 被引量: 0发表: 2020年 Tumor organoids for cancer research and personalized medici...
The recent advances inin vitro3D culture technologies, such as organoids, have opened new avenues to improve basic and clinical cancer research. Up to now, highly efficient establishment of organoids can be achieved from both normal and malignant patient tissues. ...