We define this model system and describe some key studies in which organoid culture models were employed to investigate cellular strategies and molecular mechanisms driving cancer initiation and progression, highlighting research questions for which this model is particularly well suited. In addition, as ...
The organoids, which are described in a study recently published in the journal Cancer Discovery, closely mimic the cellular, molecular, and architectural features of myelopoietic (blood cell-producing) bone marrow. Supporting Cancer Cells in Micro-Environments The research also showed that the organo...
3D Organoids Lead the Way for Personalized Cancer Therapy As oncology researchers continue to find immense value in the applications of3D organoidsfor their work, one area stands to gain a great deal from the advancements of thesein vivo-like environments and c...
et al. Mouse and human urothelial cancer organoids: a tool for bladder cancer research. Proc. Natl Acad. Sci. USA 116, 4567–4574 (2019). Article CAS PubMed PubMed Central Google Scholar Kretzschmar, K. & Clevers, H. Organoids: modeling development and the stem cell niche in a dish...
Sign up for theNature Briefing: Cancernewsletter — what matters in cancer research, free to your inbox weekly. Email address Sign up I agree my information will be processed in accordance with theNatureand Springer Nature LimitedPrivacy Policy....
From Stem Cell Research to Three-Dimensional Organoids and Their Applications in Cancer Research: Meeting Report on the 9th International Meeting of the St... S Langer,PA Horn,S Heinrichs - 《Cellular Reprogramming》 被引量: 1发表: 2017年...
K. Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer. Cell. Mol. Gastroenterol. ... S Prasad,A Chandra,E Lonardo,... - 《Cancer Research》 被引量: 0发表: 2020年 Clinical applications of 3D normal and breast cancer organ...
In this review article, we discuss current applications and advantages of organoid models in the translational research of GI cancers with a particular focus on primary liver cancer that currently lack effective curative treatments.Copyright 2019. Published by Elsevier B.V....
Breast cancer is one of the leading causes of cancer mortality among women. The main causes of death are related to recurrence and metastasis. One major limitation in the breast cancer research field is that there are few in vitro models of breast cancer able to predict clinical patients' outc...
The recent advances inin vitro3D culture technologies, such as organoids, have opened new avenues to improve basic and clinical cancer research. Up to now, highly efficient establishment of organoids can be achieved from both normal and malignant patient tissues. ...