Organoids derived from epithelial tumors have recently been utilized as a preclinical model in basic and translational studies. This model is considered to represent the original tumor in terms of 3D structure,
类器官 (Organoids) 技术:类器官是细胞衍生的体外 3D 器官模型,可在模拟内源性细胞组织和器官结构的环境中研究生物学过程,例如细胞行为、组织修复以及对药物或突变的反应。重要的是,3D 体外模型保留了体内肿瘤的组织病理学特征,包括患者特异性药物反应。类器官是一项重大技术突破,在药物筛选、疾病建模、基因编辑和移植...
Chromosomal instability (CIN) is involved in about 70% of colorectal cancers (CRCs) and is associated with poor prognosis and drug resistance. From a clinical perspective, a better knowledge of these tumour’s biology will help to guide therapeutic strat