3dGRO® Human CRC Organoids (ISO34); Synonyms: organoid, PDO, cancer organoid, tumor organoid, 3d cell culture, colorectal cancer; find Sigma-Aldrich-SCC500 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldri
Human CRC organoids derived from CRC patients' primary tumor samples closely recapitulate several properties of the original tumor and provide a platform for personalized therapy design.2,3 However, the dependence of resected primary samples of PDO model limited its application in mCRC patients. ...
Organoids are generated from various types of stem cells, which are induced to form microscopic cell clusters and cultured in vitro as 3D structures; these clusters are also known as “mini-organs” because they mimic the in vivo structures and functions of the corresponding organs.53Organoid for...
Single-cell karyotype sequencing confirmed heterogeneity of copy number alterations in tumor PDOs and showed that monoclonal lines evolved novel karyotypes over time in vitro. We conclude that ongoing CIN is common in colorectal cancer organoids, and propose that CIN levels and the tolerance for ...
Human colonic organoids Hydrogel Intestinal stem cells 1. Introduction Since the pivotal discovery of effective culture protocols for intestinalorganoids[1], organoid culture development has rapidly evolved, and is now being used in a vast array of different fields of life science research. The diagn...
Colorectal cancer (CRC) progression is a complex process that is not well understood. We describe an in vitro organ-on-chip model that emulates in vivo tissue structure and the tumor microenvironment (TME) to better understand intravasation, an early step in metastasis. The CRC-on-chip incorp...
4. Colorectal Cancer (CRC) Organoids A living biobank of 22 patient-derived colorectal tumor organoids was established representing the major CRC molecular subtypes. Normal organoids from healthy epithelium were also generated. Histological analyses revealed similar architecture between organoid/tumor pairs...
However, the extent to which patient-derived tumor organoids recapitulate the response of in vivo tumors to a given drug remains obscure. To gain insights into the pharmacobiology of human colorectal cancer (CRC), we here created a robust drug screening platform for patient-derived colorectal ...
Tumor deposits (TDs) represent a specific form tumor metastasis observed in colorectal cancer (CRC). The lack of successfully established cell lines for TD
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening 10.7554/eLife.18489.001Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this di... CS Verissimo,RM Overmeer,P Bas,... - ...