Single-cell RNA (scRNA) and T cell receptor sequencing highlighted the heterogeneity of these cells and revealed therapeutically targetable exhausted effector and clonally expanded tissue resident memory CD8+ T subpopulations, likely representing tumor-specific cells. Checkpoint blockade therapy in an ...
Long-term persistence of clonally expanded T cells in patients with polymyositis. Ann. Neu- rol. 56: 867- 872.Benveniste O, Herson S, Salomon B et al. Long-term persistence of clonally expanded T cells in patients with polymyositis. Ann Neurol 2004; 56:867-72....
Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8+ TEMRA cells in the cerebrospinal fluid of patients with ...
Furthermore, single cell RNA sequencing revealed their enhanced T cell receptor (TCR) signaling. Notably, by utilizing multiple single cell TCR sequencing strategies on a third cohort, we discovered clonally expanded CD8+ TEMRA cells in patient cerebrospinal fluid (CSF). Finally, we used machine ...
Here, using Setx knock-in mice that carry the ALS4-causative L389S mutation, we describe an immunological signature that consists of clonally expanded, terminally differentiated effector memory (TEMRA) CD8 T cells in the central nervous system and the blood of knock-in mice. Increased ...
(1998). "CD57+/CD28- T cells in untreated hemato-oncological patients are expanded and ... Van,den,Hove,... - 《Leukemia》 被引量: 16发表: 1998年 A single course of 2-chloro-deoxyadenosine does not eradicate leukemic cells in hairy cell leukemia patients in complete remission. The ...
et al. Clonally expanded T cells in hairy cell leukemia patients are not leukemia specific. Leukemia 18, 176–178 (2004). https://doi.org/10.1038/sj.leu.2403149 Download citation Received09 July 2003 Accepted20 July 2003 Published02 October 2003 Issue Date01 January 2004 DOIhttps://doi.org...
We also demonstrate that these clonally expanded GZMB +CD8 +cells are present in RA synovium. These findings suggest that cytotoxic CD8 +T cells targeting citrullinated antigens have a role in contributing to synovitis and joint tissue destruction in ACPA+ RA.The study was supported by following ...
Many studies have suggested that T cells against tumor neoantigens are critical mediators of response to checkpoint blockade. We showed previously that neoantigen-specific CD8 T cells in cancer patients responding to anti-PD-L1 (atezolizumab) therapy express high levels of CD57 and KLRG1. Here, ...
Distribution of double-negative (CD4- CD8-, DN) T subsets in blood and synovial fluid from patients with rheumatoid arthritis Double-negative (CD4- CD8-) T (DNT) cells have been postulated to be potentially autoreactive. However, the role of DNT cells in rheumatoid arthritis (RA) ... MF...