Somatic mutation of the 5' noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma. Am.J.Pathol. 2000;156:1017-1024.Szereday, Z. , Csernus, B. , Nagy, M. , Laszlo, T. , Warnke, R.A. & ...
Somatic mutation of the 5' noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation ... Somatic mutation of the 5' noncoding region of the BCL- 6 gene is associated with intraclonal diversity and clonal selection in ...
Diversity and clonal selection in the human T-cell repertoire. Proc. Natl Acad. Sci. USA 111, 13139–13144 (2014). Article CAS Google Scholar Kuo, C. T. & Leiden, J. M. Transcriptional regulation of T lymphocyte development and function. Annu. Rev. Immunol. 17, 149–187 (1999). ...
The improved algorithm included orthogonal crossover, simplex crossover, clone and selection. The idea of evolutionary computation was integrated into clone selection and a new mutation operator was proposed. The new algorithm can guarantee the diversity of the population and improve the global search ...
We observed diversity in resistant types across several single-cell-derived cancer cell lines and cell types treated with a variety of drugs. The diversity of resistant types as a result of the variability in intrinsic cell states may be a generic feature of responses to external cues. This is...
sinensis) is between 0.229 and 0.803, and the mean value is 0.543; the observed heterozygosity () ranges from 0.103 to 0.683, with an average of 0.340, while the genetic identity varies from 0.267 to 0.984. Based on tea-making properties, the genetic diversity in the "black-green tea" gro...
As the diversity of single-cell technology proliferated, the simultaneous conduction of multiple omics at the single-cell level (single-cell multiomics) came to the front, enabling a more precise definition of cellular characterization and comprehensive exploration of transcriptional regulatory mechanisms ...
Multistep carcinogenesis is the currently accepted hypothesis to explain genetic diversity in tumors [8]-[10]. This hypothesis is based on the notion that somatic mutations are rare events that are unlikely to co-occur in different single normal cells, and that the mutations leading to the genet...
The clonal selection theory is employed to describe the basic features of an immune response to an antigenic stimulus in order to meet the requirement of diversity in the antibody population. In our proposed strategy, dimensionality reduction is formulated as an optimization problem that searches an ...
We were interested in the cellular population diversity at different stages of an isogenic TI CLD platform22. This platform is based on simultaneous dual-plasmid RMCE-mediated targeted integration into a single genomic locus thus generating isogenic cells, which theoretically excludes variability derived ...