The article discusses research being done on the clonal diversity of the immune system's T lymphocyte subsets. It references a study by Vikram Palanivel and colleagues in a 2007 issue of "Science." According to the researchers, the subsets arise from the first, asymmetric division that a ...
Lymph nodes had significantly lower levels of clonal unevenness, thus by extension, higher levels of clonal diversity (measured by the normalized mean clone size index (Fig. 4a) and Shannon and Gini indices (Extended Data Fig. 5a), P < 0.05 with effect sizes >1.33). However, there ...
BCR repertoire diversity is a key feature of the humoral immune system and creates the potential for recognition of the wide variety of antigens. To evaluate the BCR repertoire diversity, we first analyzed the Simpson index, Shannon–Wiener index, and Chao 1 index values for amino acid sequence...
(Sup Fig.8A). This suggests that roughly a fifth of the injected cells are able to engraft and grow in the mammary gland. As clone diversity was again similar between NSG mice and WT mice, this confirms that the immune system does not play a major role in restricting the growth of 4...
Multicode STBC-MIMO systems can provide flex- ibility in the diversity-multiplexing gain tradeoff. It is worth noting that multicode operation can provide additional degrees of freedom in the code domain to achieve high data rates. Mean- while an immune-clonal-selection-based minimum-BER detection...
We postulate these interactions reflect co-evolution of the host immune system and SpA, which during infection results in immune recruitment of an extraordinarily high prevalence of B cells in the repertoire that subverts the augmentation of protective defenses. Herein, we provide the first evidence ...
As the diversity of single-cell technology proliferated, the simultaneous conduction of multiple omics at the single-cell level (single-cell multiomics) came to the front, enabling a more precise definition of cellular characterization and comprehensive exploration of transcriptional regulatory mechanisms ...
Clonal evolution in cancer is intimately linked to the concept of intratumor cellular diversity, as the latter is a prerequisite for Darwinian selection at the micro-level. It has been frequently suggested in the literature that clonal evolution can be promoted by an elevated rate of mutation in ...
The new algorithm can guarantee the diversity of the population and improve the global search ability. Theoretical analysis has proved that ICSA converges to the global optimum. Different functions were utilized to test this method and the simulation results have shown that the proposed ICSA algorithm...
展开 关键词: Animals Mice B-Lymphocytes Immunoglobulin Variable Region Blotting, Southern Restriction Mapping Base Sequence Sequence Homology, Nucleic Acid Antibody Diversity Gene Rearrangement, B-Lymphocyte, Heavy Chain DOI: 10.1002/j.1460-2075.1988.tb03251.x 被引量: 264 年份...