Selection by parasites for clonal diversity and mixed mating. Philos. Trans. R. Soc. Lond. B. 346:271- 280.Lively, C. M. and R. S. Howard. 1994 . Selection by parasites for clonal diversity and mixed mating. Phil. Trans. R. Soc. Lond. B 46: 271 – 281 ....
Somatic mutation of the 5' noncoding region of the BCL- 6 gene is associated with intraclonal diversity and clonal selection in histological transformation... Z Szereday,B Csernus,M Nagy,... - 《American Journal of Pathology》 被引量: 63发表: 2000年 Somatic Mutation of the 5′ Noncoding...
The evolutionary timing of the observed positive selection depended on the histology for a number of genes. In LUAD, significant truncal but not subclonal selection ofB2Mpoint mutations was observed, whereas in LUSC, there was evidence for significant subclonal but not truncal selection (Fig.3a)...
2c). We analyzed the clonal diversity of respective CHO cell pools expressing M1-M3 during stable pool selection at two time points: (i) pre-selection at day five post-transfection and (ii) post-selection at the day the cell population reached ~ 80%viability....
As the diversity of single-cell technology proliferated, the simultaneous conduction of multiple omics at the single-cell level (single-cell multiomics) came to the front, enabling a more precise definition of cellular characterization and comprehensive exploration of transcriptional regulatory mechanisms ...
In addition, high levels of clonal diversity were recently suggested among splenic CD4+ T cells during Plasmodium chabaudi infection through the sequencing of T cell receptor β (TCRβ) chains.17 Together, these data suggest that substantial clonal, phenotypic, and spatial diversity likely emerges ...
We took advantage of an inducible murine Confetti allele [37,46], while the Zon laboratory utilized the Zebrabow system [45], to track clonal diversity of the early hematopoietic system. Both systems allow for the labeling of pools of HSC precursors with multiple distinct fluorophores. The Cre...
Multistep carcinogenesis is the currently accepted hypothesis to explain genetic diversity in tumors [8]-[10]. This hypothesis is based on the notion that somatic mutations are rare events that are unlikely to co-occur in different single normal cells, and that the mutations leading to the genet...
In contrast, an average of 4544 barcodes were detected in primary tumors (range: 3063–5648), and there was evidence for a selection for individual barcodes (Fig. 2a, b). To quantitatively assess the clonal complexity of each tumor we used the Shannon Diversity index30, a measure of the...
2298Accesses 4Citations 1Altmetric Metrics Abstract Hematopoietic stem cells (HSCs) are functionally and genetically diverse and this diversity decreases with age and disease. Numerous systems have been developed to quantify HSC diversity by genetic barcoding, but no framework has been established to emp...