The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production. J. Immunol. 181: 5522-5529.Itoh, K., Watanabe, A., Funami, K., Seya, T. Matsumoto, M. (2008) The clathrin- mediated endocytic pathway participates in dsRNA-induced IFN-beta production...
The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production. TLR3 and cytoplasmic RIG-I-like receptor (RLR) recognize virus-derived dsRNA and induce type I IFN production in a distinct manner. Human TLR3 localizes to... K Itoh,A Watanabe,K Funami,... - 《Journ...
The Epithelial Na+/H+Exchanger, NHE3, Is Internalized through a Clathrin-mediated Pathway The Epithelial Na+/H+ Exchanger, NHE3, Is Internalized through a Clathrin- mediated Pathway. J. Biol. Chem. 1999; 274(53):37551-37558. [PubMed: ... CW Chow,S Khurana,M Woodside,... - 《...
The pathway(s) utilized by NHE3 have not been defined. The purpose of the current study was to identify the mechanism(s) that mediate NHE3 internalization and to analyze the factors required for recycling of the internalized exchangers to the plasma membrane. To this end, we used cells ...
To date, the best characterized pathway is clathrin-mediated endocytosis. This chapter presents an overview of the mechanisms of clathrin-mediated endocytosis and how itis regulated. We provide a mechanistic description of how a clathrin-coated vesicle (CCV) is formed, from the stages of initiation...
Aβ42. Active form of γ-secretase is constitutively endocytosed via the clathrin-mediated pathway in a CALM dependent manner. Alteration in the rate of clathrin-mediated endocytosis of γ-secretase causes a shift in its steady-state localization, which consequently impacts on the production ratio ...
Clathrin-mediated endocytosis (CME) is one of the major pathway through which cells internalize nutrients and membrane proteins. It occurs on the membrane via clathrin-coated pits (CCPs). In this thesis, we studied CCPs' behavior when cells are under spatial constraints. In the first two project...
Clathrin-mediated endocytosis is the most common pathway used by viruses and pathogens for entering host cells. The inhibitors of clathrin-mediated endocytosis may block the entry of viruses and pathogens, thus prevent viral infection. For the inhibitors do not directly act on the virus itself, it...
NKCC2 trafficking regulates NaCl reabsorption by the thick ascending limb (THAL). NKCC2 undergoes endocytosis from the apical membrane, but the endocytic pathways for NKCC2 are unknown. We hypothesized that in THALs, NKCC2 is internalized via a clathrin mediated pathway. We found that clathrin...
The present work significantly advances the understanding of this proposed pathway by providing quantitative and comprehensive evidence not only supporting this model (Figure 1), but also revealing the importance of this mechanism in retrieving vesicles during depolarization in excitable cells (Figure 2)....