Endocytosis in plants has an essential role not only for basic cellular functions but also for growth and development, hormonal signaling and communication with the environment including nutrient delivery, toxin avoidance, and pathogen defense. The major endocytic mechanism in plants depends on the coat...
Clathrin lattices at the plasma membrane coat both invaginated and flat regions forming clathrin-coated pits and clathrin plaques, respectively. The function and regulation of clathrin-coated pits in endocytosis are well understood but clathrin plaques r
Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent ... AV Vieira,C Lamaze,SL Schmid - 《Science》 被引量: 1617发表: 1996年 Clathrin-mediated endocytosis in AP-2–depleted cells We have used RNA...
Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat. Rev. Mol. Cell Biol. 12, 517–533 (2011). Article CAS PubMed Google Scholar Sigismund, S. et al. Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol. Rev. 92, 273–366 (...
ficsequencemotifsinthecytosolicdomainsofrecep-torsandothertransmembranecargomolecules.Endocyticcargothatisconcen-tratedinthismanner,suchassignalingreceptors,mayregulatethestability,size,anddynamicsofindividualclathrincoatsandtherebyinfluenceendocytosis.1.1IntroductionEndocytosisisaprocessbywhichcellsinternalizeextracellular...
While the molecular mechanisms mediating sorting of GPCRs to the degradative pathways is out of scope for this commentary, it is important to note that as for recycling GPCRs, GPCR trafficking to the lysosome can be regulated by GPCR signaling. For example, degradation of the dopamine D2 and...
Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It is responsible for the uptake of transmembrane receptors and transporters, for remodeling plasma membrane composition in response to environmental changes, and for regulating cell surface signaling. CME occurs via ...
Macromolecules gain access to the cytoplasm of eukaryotic cells using one of several ways of which clathrin-dependent endocytosis is the most researched. Although the mechanism of clathrin-mediated endocytosis is well understood in general, novel adaptor proteins that play various roles in ensuring speci...
Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis Summary The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth fac... Bisei,Ohkawara,and,... -...
Clathrin-mediated endocytosis (CME) is one of the major pathway through which cells internalize nutrients and membrane proteins. It occurs on the membrane via clathrin-coated pits (CCPs). In this thesis, we studied CCPs' behavior when cells are under spatial constraints. In the first two project...