This review provides a comprehensive examination of the role of clathrinmediated endocytosis (CME) in Alzheimer's disease (AD) pathogenesis, emphasizing its impact across various cellular contexts beyond neuronal dysfunction. In neurons, dysregulated CME contributes to synaptic dysfu...
Clathrin-mediated endocytosis was first described over 5 decades ago. Since its discovery, over 50 proteins have been shown to be part of the molecular machinery that generates the clathrin-coated endocytic vesicles. These proteins and the different steps of the endocytic process that they mediate ...
L. Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274, 2086–2089 (1996). Article CAS PubMed Google Scholar Nevins, A. K. & Thurmond, D. C. Caveolin-1 functions as a novel CDC42 guanine nucleotide dissociation inhibitor in pancreatic β-cells. J. Biol. Chem...
Clathrin-mediated endocytosis (CME), which occurs at clathrin coated pits (CCPs), requires the major coat proteins, clathrin and AP2 complexes together with a myriad of endocytic accessory factors and lipids. CME proceeds through multiple stages, including initiation, stabilization of nascent CCPs, ...
2.3.1.3.1Clathrin-mediated endocytosis by GRKs and arrestins The appearance of the large proteinclathrinincoated vesicleswas first described byPearse (1976). Almost two decades later,von Zastrow and Kobilka (1994)proposed the involvement of theclathrin-coated vesicle pathway in mediatinginternalisation...
Although the mechanism of clathrin-mediated endocytosis is well understood in general, novel adaptor proteins that play various roles in ensuring specific regulation of the mentioned process are being discovered all the time. This review provides a detailed account of the mechanism of clathrin-mediated...
clathrin-mediated endocytosis 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 网格蛋白介导的内吞作用 翻译结果2复制译文编辑译文朗读译文返回顶部...
Clathrin-mediated endocytosis is the main portal of entry into the cell for many soluble and membrane molecules. Clathrin-coated vesicles are formed from the plasma membrane in a sequence of coordinated protein-lipid and protein-protein interactions, starting with adaptor-mediated recruitment of clathri...
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