Clathrin and the endocytosis machinery has recently been described as being required in mammalian cells for the internalization of large particles including pathogenic bacteria, fungi, and large viruses. These apparently unexpected observations, within the framework of the classical mechanisms for the format...
Clathrin-mediated endocytosis is well-described and universal. Clathrin independent forms are poorly understood and limited to specific cell types or lineage states. Endocytosis in T cells is inter alia regulating plasma membrane immune receptors and signaling, including internalization and recycling of T...
This form of endocytosis is also important because it can transport extracellular liquid through the cell without it interacting or affecting the cytoplasm. As mentioned, this cell drinking occurs in every type of cell. Receptor-Mediated Endocytosis – Clathrin-Mediated And Caveolae-Mediated Endocytosis...
By contrast, soluble Erns is taken up by clathrin-mediated endocytosis that enables this RNase to effectively degrade the viral PAMPs prior to TLR activation (B). The annotation of the elements in the figure is depicted in the panel on the right. An endosomal location of Erns is also in ...
Currently, there is a revived interest in virus entry into animal cells because it is evident that incoming viruses make use of numerous endocytic pathways that are otherwise difficult to study. Besides the classical clathrin-mediated uptake route, viruses use caveolae-mediated endocytosis, lipid-raft...
are endosomes that contain liquids containing suspended substances. Phagocytosis, on the other hand, results in the formation of phagosomes, which contain pathogens such as bacteria and viruses. Endocytosis mediated by receptors, on the other hand, results in clathrin-coated endosomes. This...
endocytosis, including clathrin and caveolae-mediated, or receptor-independent macropinocytosis reached the same conclusionthat ATP mediated endocytosis is not involved in Tat protein penetration [7–10].However,this issue is controversial,as other studies found evidence for endocytosisin Tat protein import...
the movement of BRs from the inside to the outside of the cell is necessary to initiate BR signal transduction and might thus—despite membrane permeability of these sterol compounds—require a plasma membrane exporter. Thus, it would be worth examining whether BR transport is mediated by transpor...
The abundance of PHT1 protein is also monitored by NLA at the plasma membrane; PHT1s ubiquitinated by NLA undergo clathrin-mediated endocytosis and are destined for endosomal sorting to vacuoles (Lin et al., 2013). Notably, several lines of genetic evidence have shown that AtPHF1 and AtPHT1...
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process J. Cell Biol., 160 (3) (2003), pp. 321-328 Google Scholar [13] A.M. Friedlander Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process J. Biol. Chem., 261...