The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production. J. Immunol. 181: 5522-5529.Itoh, K., Watanabe, A., Funami, K., Seya, T. Matsumoto, M. (2008) The clathrin- mediated endocytic pathway participates in dsRNA-induced IFN-beta production...
The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production. TLR3 and cytoplasmic RIG-I-like receptor (RLR) recognize virus-derived dsRNA and induce type I IFN production in a distinct manner. Human TLR3 localizes to... K Itoh,A Watanabe,K Funami,... - 《Journ...
The Epithelial Na+/H+Exchanger, NHE3, Is Internalized through a Clathrin-mediated Pathway The Epithelial Na+/H+ Exchanger, NHE3, Is Internalized through a Clathrin- mediated Pathway. J. Biol. Chem. 1999; 274(53):37551-37558. [PubMed: ... CW Chow,S Khurana,M Woodside,... - 《...
J. et al. Trafficking of prion proteins through a caveolae-mediated endosomal pathway. J. Cell Biol. 162, 703–717 (2003). Article CAS PubMed PubMed Central Google Scholar Shyng, S. L., Moulder, K. L., Lesko, A. & Harris, D. A. The N-terminal domain of a glycolipid-anchored...
Several mechanisms are utilized to internalize plasma membrane proteins, including clathrin-mediated coated vesicle formation (27), generation of caveolae (28, 29), or other uncoated vesicles (28, 30), and actin-dependent macropinocytosis. The pathway(s) utilized by NHE3 have not been defined. Th...
Using both pharmacological and genetic approaches we demonstrate that MDA-7/IL-24 internalization employs the clathrin-mediated endocytic pathway leading to degradation of receptors via the lysosomal/ubiquitin proteosomal pathway. This clathrin-mediated endocytosis is dynamin-dependent. This study resolves ...
Aβ42. Active form of γ-secretase is constitutively endocytosed via the clathrin-mediated pathway in a CALM dependent manner. Alteration in the rate of clathrin-mediated endocytosis of γ-secretase causes a shift in its steady-state localization, which consequently impacts on the production ratio ...
To date, the best characterized pathway is clathrin-mediated endocytosis. This chapter presents an overview of the mechanisms of clathrin-mediated endocytosis and how itis regulated. We provide a mechanistic description of how a clathrin-coated vesicle (CCV) is formed, from the stages of initiation...
Clathrin-mediated endocytosis is the most common pathway used by viruses and pathogens for entering host cells. The inhibitors of clathrin-mediated endocytosis may block the entry of viruses and pathogens, thus prevent viral infection. For the inhibitors do not directly act on the virus itself, it...
Clathrin-mediated endocytosis (CME) is one of the major pathway through which cells internalize nutrients and membrane proteins. It occurs on the membrane via clathrin-coated pits (CCPs). In this thesis, we studied CCPs' behavior when cells are under spatial constraints. In the first two project...