Most classical chemotherapeutic agents interact with tumour DNA, whereas monoclonal antibodies and small molecules are directed against proteins. The endothelium and extracellular matrix may be affected also by specific antibodies and small molecules.关键词: Antineoplastic drugs chemotherapy classification ...
A great number of anticancer agents are under clinical investigation at this moment. Some of them belong to classic groups of chemotherapy, but others are the first of new families of drugs. For clinicians, it is important to have the main groups in mind and, for this reason, we propose ...
Topoisomerase inhibitors are chemotherapy medications that prevent topoisomerase enzymes from working (topoisomerase I and II). Topoisomerase enzymes regulate the alteration of the DNA structure required for replication during chemotherapies. Topoisomerase I Inhibitors:Irinotecan, topotecan Topoisomerase II Inhibito...
research, cancer registries, and public health monitoring worldwide. For the first time since the inception of the classification over 60 years ago, the current series (5th edition) has been developed within
CytokinesFluconazoleMonocytesNitric Oxide抗真菌药念珠菌, 白色细胞活素类氟康唑An abstract is unavailable. This article is available as a PDF only.doi:10.1128/AAC.45.1.96-104.2001ALFORDLELAND BAntimicrob Agents ChemotherAntimicrobial Agents & Chemotherapy...
Therapeutic profiling revealed marked interpatient variability in the response to a single chemotherapy agent, but glucomet-PDAC organoids were generally more resistant to chemotherapeutic agents than lipomet-PDAC organoids (Figures 2E and 2F). To determine whether PDAC organoids can precisely reflect ...
Cancer chemotherapyImmunogenic cell deathIntegrated stress responseTranscription inhibitionImmunogenic cell death (ICD) inducers are often identified in phenotypic screening campaigns by the release or surface exposure of various danger-associated molecular patterns (DAMPs) from malignant cells. This study aimed...
strong prognostic value in terms of chemotherapy outcome, and the Primitive versus Mature axis capturing ex vivo drug sensitivity [59]. This study incorporated the stem-cell feature with the AML hierarchies, providing a novel framework for understanding biomarkers underlying different hierarchical ...
During the viral entry, the N-heptad repeat (NHR) and C-heptad repeat (CHR) of GP41 switch to a six-helix bundle (6-HB) structure which binds to the human cell membrane and drives the viral fusion into the human cells. Many antiviral agents have been developed to target the ...
Acutemyeloid leukemia(AML) arises from the myeloid lineage. Some myelodysplastic ormyeloproliferative disordersmay turn into AML[11]. Chemotherapy may also cause predisposition to AML. Especially chemotherapeutic regimens involvingtopoisomerase IIinhibitors[12]oralkylating agents[13]were linked to such a pred...