Anticancer drugs may act at different levels: cancer cells, endothelium, extracellular matrix, the immune system or host cells. The tumour cell can be targeted at the DNA, RNA or protein level. Most classical chemotherapeutic agents interact with tumour DNA, whereas monoclonal antibodies and small ...
Anticancer drugs may act at different levels: cancer cells, endothelium, extracellular matrix, the immune system or host cells. The tumour cell can be targeted at the DNA, RNA or protein level. Most classical chemotherapeutic agents interact with tumour DNA, whereas monoclonal antibodies and small ...
ancillary use of immunohistochemical stains has been introduced to the classification.Due to new discoveries of activating mutations in pulmonary adenocarcinomas, the use of targeted therapy, and histology-based recommendation to chemotherapeutic drugs, it is now crucial that pathologists subclassify NSCLC ...
2023, Medicinal Chemistry of Chemotherapeutic Agents: a Comprehensive Resource of Anti-infective and Anti-cancer Drugs Show abstract Advances in the synthesis of antiviral agents from carbohydrate-derived chiral pools 2023, Journal of Carbohydrate Chemistry Show abstract Brain antioxidants and hippocampal mic...
in the South American arrow poison,curare(obtained fromChondrodendron tomentosum), and is used as a muscle relaxant in surgery. Two alkaloids,vincristineandvinblastine(fromCatharanthus roseus, formerlyVinca rosea), are widely used as chemotherapeutic agents in the treatment of many types ofcancer. ...
We further applied pRRophetic package to estimate the chemotherapeutic response of sorafenib, which fitted the ridge regression model based on baseline gene expression and drug sensitivity of the cell line, thus allowing the prediction of the clinical chemotherapeutic response using only patients’ ...
Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78. The findings also prompt the deliberation that the resistance can be caused during combined administration of chemotherapeutic drugs and Chinese herbal medicines... JL...
Table S2. Differential metabolites of the two metabolic subtypes, related to Figure 1 Table S3. Glucomet-PDAC and lipomet-PDAC signature genes, related to Figure 1 Table S4. Normalized AUC of drug sensitivity in PDAC organoids with 4 chemotherapeutic drugs, related to Figure 2 Table S5. Tiss...
“Possible” is defined as drugs with similar mechanisms of action as those in the “definite” or “likely” categories but which have not yet been studied (e.g., drugs used to treat attention-deficit disorder). Lastly, an “unlikely” association is defined as one in which a drug has ...
Gastric carcinoma (GC) is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. Despite better control over known risk factors and development of new chemotherapeutic and targeted agents, in the United States, the 5-year overall survival for GC patients ...