Diseases such as diabetes can damage nerves. Or an injury can damage them. Certain chemotherapy drugs may cause nerve damage. Nerves can also be damaged by a stroke or anHIV infection, among other things. Pain could be from damage to the central nervous system (CNS), which is made up of...
Several editions of the World Health Organization (WHO) classifications of lympho-hemopoietic neoplasms in 2001, 2008 and 2016 served as the international standard for diagnosis. However, despite significant progress in the field, there has been no update since the WHO 2016 classification, here referr...
ChemotherapyCytotoxic drug handlingCytotoxic drugsError classificationsPharmaceutical analysisPrescription errorsObjective:To quantify the amount of potential prescription errors for anticancer drugs in order to improve the quality of care.#Setting:The cytotoxic reconstitution unit at the Laennec Hospital in Paris...
Timeline of FDA approvals for the treatment of AML. CRi, complete remission with incomplete count recovery; dx, diagnosed; FDA, Food and Drug Administration; IC, intensive chemotherapy; LDAC, low dose cytarabine; MDS, myelodysplasia; Mut, mutated; R/R, relapsed and refractory. Case 1 A 45-...
Gastric cancer (GC) is a highly aggressive and life-threatening malignancy. Even with radical surgical removal and front-line chemotherapy, more than half of GCs locally relapse and metastasize at a distant site. The dismal outcomes reflect the ineffecti
The impact of targeted therapies in glioma has been modest. All the therapies that have demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation, chemotherapy (temozolomide and PCV [procarbazine, lomustine, vincristine]), and tumor-treating fields, are based ...
Mice models have shown that after cancer cell line injection in an immunocompetent host and clearance due to cytotoxic chemotherapy, subsequent rechallenge using the same cell line will lead to rejection only in the case of immunogenic cell death (Casares et al., 2005). The fact that myeloid ...
Gastric cancer (GC) is a highly aggressive and life-threatening malignancy. Even with radical surgical removal and front-line chemotherapy, more than half of GCs locally relapse and metastasize at a distant site. The dismal outcomes reflect the ineffecti
[90,96,97]. B-symptoms are common and approximately 25% of patients develop haemophagocytic lymphohistiocytosis [90,96,97]. Multiagent chemotherapy and radiotherapy are the treatment of choice although response to treatment is often poor: median survival is 31 months and the 5-year survival 19.9...
Fig. 5. Characteristics of the substituted molecular (SM) types and probable treatments. Abbreviations: CT, chemotherapy; dMMR, mismatch repair deficient; EBVa, Epstein-Barr virus associated; EMT, epithelial-mesenchymal transformation; NOS/P53m, not otherwise specified/P53 mutated phenotype; NOS/P53...