Even with radical surgical removal and front-line chemotherapy, more than half of GCs locally relapse and metastasize at a distant site. The dismal outcomes reflect the ineffectiveness of a one-size-fits-all approach for a highly heterogeneous disease with diverse etiological causes and complex ...
Several editions of the World Health Organization (WHO) classifications of lympho-hemopoietic neoplasms in 2001, 2008 and 2016 served as the international standard for diagnosis. However, despite significant progress in the field, there has been no update since the WHO 2016 classification, here referr...
Gastric cancer(GC) is a highly aggressive and life-threatening malignancy.Even with radical surgical removal and front-line chemotherapy,more than half of GCs locally relapse and metastasize at a distant site.The dismal outcomes reflect the ineffectiveness of a one-size fits-all approach for a ...
The impact of targeted therapies in glioma has been modest. All the therapies that have demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation, chemotherapy (temozolomide and PCV [procarbazine, lomustine, vincristine]), and tumor-treating fields, are based o...
Diseases such as diabetes can damage nerves. Or an injury can damage them. Certain chemotherapy drugs may cause nerve damage. Nerves can also be damaged by a stroke or anHIV infection, among other things. Pain could be from damage to the central nervous system (CNS), which is made up of...
Gastric cancer (GC) is a highly aggressive and life-threatening malignancy. Even with radical surgical removal and front-line chemotherapy, more than half of GCs locally relapse and metastasize at a distant site. The dismal outcomes reflect the ineffecti
Gastric cancer (GC) is a highly aggressive and life-threatening malignancy. Even with radical surgical removal and front-line chemotherapy, more than half of GCs locally relapse and metastasize at a distant site. The dismal outcomes reflect the ineffecti
Fig. 5. Characteristics of the substituted molecular (SM) types and probable treatments. Abbreviations: CT, chemotherapy; dMMR, mismatch repair deficient; EBVa, Epstein-Barr virus associated; EMT, epithelial-mesenchymal transformation; NOS/P53m, not otherwise specified/P53 mutated phenotype; NOS/P53...
ChemotherapyCytotoxic drug handlingCytotoxic drugsError classificationsPharmaceutical analysisPrescription errorsObjective:To quantify the amount of potential prescription errors for anticancer drugs in order to improve the quality of care.#Setting:The cytotoxic reconstitution unit at the Laennec Hospital in Paris...
In advanced tumors, therapeutic options beyond traditional chemotherapy are currently restricted to immunotherapy, antiangiogenic agents, and anti-HER2 drugs. Key advancements in molecular pathology for GC include the release of molecular classifications by TCGA and the ACRG. These groups conducted the ...