“metronomics” an appealing choice for the treatment of cancer, such as the use of approved and known drugs, which reduces the time needed to enter the clinic, including oral administration, fewer side effects, low toxicity, low costs due to the use of generally out-of-patent drugs, a ...
Stratification was performed based on PD-L1 expression status, histological classification (SCC vs. non-SCC), and smoking status (Fig. 1). Baseline demographic and disease characteristics were evenly distributed across both treatment groups (Table 1). Fig. 1 CONSORT diagram of the CHOICE-01 study...
Anticancer Drugs. 1998;9:191-2019625429Google ScholarCrossref 19. Burris HA III, Moore MJ, Andersen J. et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-2413919...
Then, chemotherapy drugs were administered via the placed catheter. This regimen was repeated once every 3 weeks. Treatment cycles continued for two cycles. Treatment Modalities. Patients proceeded to surgery during the 2–3 weeks after completion of the neoadjuvant chemotherapy. After laparotomy, ...
Seven patients received maintenance chemotherapy using low-dose cytarabine (five patients) or monthly courses of chemotherapy using the same drugs as during induction at reduced dosages (two patients) because of severe toxicity following induction course (four patients) or practical reasons (three ...
25,27,28 At the level of individual drugs, this association was especially pronounced for taxane agents. Decreased chemotherapy dose intensity was accompanied by an increased incidence of neutropenia. Differences in overall survival did not reach statistical significance in this small study, but the ...
stage and thus regaining the opportunity for surgery. currently, cisplatin-based doublet chemotherapy consisting of cisplatin combined with third-generation drugs (paclitaxel, gemcitabine, vinorelbine, or docetaxel) is commonly recommended as the standard treatment for patients with advanced nsclc [ 4 –...
All these districts usually planned for annual MDA are no longer necessary which has a significant impact in saving resources, logistic and drugs. The planned resources could be adequately relocated to community level where appropriate. Overall, under-treatment and over-treatment have been observed ...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event associated with several antineoplastic drugs; however, the precise risks and time course of reactions of particular drugs are not clearly understood. The aim of this study was to evaluate the relationship between anticancer agen...
We further assessed the chemotherapy sensitivity of glucomet-PDAC and lipomet-PDAC using gemcitabine (GEM), 5-fluorouracil (5-FU), irinotecan (IRI), and oxaliplatin (OXA) (four chemotherapeutic drugs that work by inhibiting DNA synthesis), which are commonly used to treat patients with PDAC (...