The blockade of cardiac transmembrane potassium channels, which is commonly seen with various antiarrhythmic drugs, plays an important role in their mechanism of action. We studied and compared the less-explored effects of three Class IA antiarrhythmics on the transient outward current (I(to)) and...
Virtually all clinical antiarrhythmic agents act by reducing ion channel conductance, w... S Nattel - 《J Cardiovasc Electrophysiol》 被引量: 1051发表: 1999年 Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac ...
Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. The voltage-gated Nav1.5 channel is essential for the propagation of action potentials in the heart. Malfunctions of this channel are known to cause heredi... H Poulin,O Theriault,MJ Beaulieu,... ...
Lenalidomide (drug class: similar structure to thalidomide; similar mechanism of action in killing cancer cells) • Lenvatinib (drug class: drugs having the shared target of VEGFR-kinase inhibitors) • Nivolumab (drug class: antibodies that inhibit PD-L1/PD-1 signaling pathway) • Osimertinib...
Kohlhardt M, Fichtner H, Fröbe U, Herzig JW (1989) On the mechanism of drug-induced blockade of Na+ currents: interaction of antiarrhythmic compounds with DPI-modified single cardiac Na+ channels. Circ Res 64:867–881 CrossRef Köppel C, Wagemann A, Martens F (1989) Pharmacokinetics ...
Conclusion: DC031050 is a highly selective hERG potassium channel blocker with a substantial safety margin of activity over neuronal potassium channels, thus holds significant potential for therapeutic application as a class III antiarrhythmic agent. Keywords: dofetilide; DC031050; class III ...
Bepridil block of cardiac calcium and sodium channels. The effects of bepridil, a new Ca channel blocking agent with reported antiarrhythmic action, were examined in single isolated ventricular cells using whole-cell patch clamp techniques. Ca currents were studied in guinea-pig ventricular ... A ...
Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action Circ Res., 68 (1991), pp. 77-84 View in ScopusGoogle Scholar 10 Sager PT, Follmer C, Uppal P, Pruitt C, Godfrey R. The effects of β-adrene...
The blocking mechanism of sodium currents by a new class I antiarrhythmic drug, Ro 22-9194, in isolated guinea-pig ventricular myocytes Senya Karasaki, Ryoichi Sato, Ryo KatoriShow moreShow less Choose an option to locate/access this article: Check if you have access through your login ...
Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their us