Electrophysiologic mechanism of action of the class III antiarrhythmic agents sematilide and clofilium: T.M. Argentieri and M.S. Carroll. Dept. of Pharmacology, Berlex Laboratories, Inc., Cedar Knolls, NJdoi:10.1016/0022-2828(90)91770-8None...
Lenalidomide (drug class: similar structure to thalidomide; similar mechanism of action in killing cancer cells) • Lenvatinib (drug class: drugs having the shared target of VEGFR-kinase inhibitors) • Nivolumab (drug class: antibodies that inhibit PD-L1/PD-1 signaling pathway) • Osimertinib...
Conclusion: DC031050 is a highly selective hERG potassium channel blocker with a substantial safety margin of activity over neuronal potassium channels, thus holds significant potential for therapeutic application as a class III antiarrhythmic agent. Keywords: dofetilide; DC031050; class III ...
Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. The voltage-gated Nav1.5 channel is essential for the propagation of action potentials in the heart. Malfunctions of this channel are known to cause heredi... H Poulin,O Theriault,MJ Beaulieu,... ...
Kohlhardt M, Fichtner H, Fröbe U, Herzig JW (1989) On the mechanism of drug-induced blockade of Na+ currents: interaction of antiarrhythmic compounds with DPI-modified single cardiac Na+ channels. Circ Res 64:867–881 CrossRef Köppel C, Wagemann A, Martens F (1989) Pharmacokinetics ...
Termination of atrial fibrillation by class Ic antiarrhythmic drugs,a paradox[A]. In King ma JH,van Hemei NM, lie KL. Atrial fibrillation a treatable disease[M]. Boston:Kluwer, 1992,265.Allessie M,Kirchhof C.Termination of atrial fibrillation by class Ic antiarrhythmic drugs, a paradox[A]....
ST segment elevation in the right precordial leads induced with class IC antiarrhythmic drugs: Insight into the mechanism of Brugada syndrome. J Cardiovasc Electrophysiol 1999;10(2):214–218.Fujiki , A. , Usui , M. , Nagasawa , H. , Mizumaki , K. , Hayashi , H. & Inoue , H. 1999...
The blocking mechanism of sodium currents by a new class I antiarrhythmic drug, Ro 22-9194, in isolated guinea-pig ventricular myocytes Senya Karasaki, Ryoichi Sato, Ryo KatoriShow moreShow less Choose an option to locate/access this article: Check if you have access through your login ...
Mechanism of action As a generalization,class III antiarrhythmicsprolong cardiac action potentials, resulting in an increase in the effective refractory period. With the exception of ibutilide, which slows outward Na+currents during repolarization, theclass III drugsblockpotassium channels. However, prope...
Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their us