Anion manipulation, a novel antiarrhythmic approach: mechanism of action. Curtis M J,Garlick P B,Ridley PD. Journal of Molecular and Cellular Cardiology . 1993Curtis M J,Garlick P B,Ridley PD. Anion manipulation a novel antiarrhythmic approach:mechanism of action[J].Journal of Molecular and ...
All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so primarily by inhibiting repolarizing potassium currents. Therefore, these compounds are often referred to as "potassium channel...
Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides the development of this group of peptides and derivatives, their mode of action and molecular mechanisms, and discusses their possible therapeutic potential... ...
( 1976 ). Arrhythmias and antiarrhythmic drugs: Mechanism of action and structure-activity relationships II . J. Pharmaceut. Sci. , 65 , 635 – 647 .Morgan PH,Mathison IW.Arrhythmias and antiarrhythmic drugs: Mechanism of action and Structure-Activity Relationships I. Journal of Pharmacological ...
β-BLOCKERS. MECHANISM OF ANTIARRHYTHMIC ACTIONInpharma Weekly -doi:10.1007/BF03288216Springer International PublishingInpharma
Of the possible medical treatments of arrhythmias, drug therapy has gained great importance. In spite of the significant progress achieved in the basic understanding of the electrophysiology and molecular biology of transmembrane ion channels and transporters underlying the mechanism of cardiac arrhythmias ...
Present results indicate that EGIS-7229 can be considered as a selective IKr blocker at low (1 M) concentration; however, its combined (class III + IV) mechanism of action is evident at concentrations of 3 M or higher. Suppression of ICa may explain the lack of development of early after...
We investigated and classified its mechanism of action according to Vaughan Williams. We have found that bergamottine at a concentration range of 5–20 μg/mL (14.7–59 μM) decreased the frequency and the force of the contraction in spontaneously beating guinea-pig right atria and ...
S‐Limonene (s‐Lim) is a monocyclic monoterpene found in a variety of plants and has been shown to present antioxidant and cardioprotective activity in experimental models of myocardial infarction. The aim of this study was to evaluate the potential mechanism by which s‐Lim...
Selective prolongation of cardiac repolarization is an effective means of suppressing a variety of cardiac arrhythmias, particularly those arising from a re-entrant mechanism. Over the past several years, a variety of novel compounds have been discovered that increase cardiac action potential duration ...