Chemotherapy agentsare divided into different categories according to their mechanism of action. The rationale behind chemotherapy is to inhibit or kill rapidly dividing cancer cells. This may be due to the drug acting at a particular point in the cell cycle (cell cycle-specific) or is independent...
Most notably, his preclinical research led to the belly bath as a way of delivering cell-cycle specific agents by continuous 4 h infusions, leading to phase I/II clinical trials of IP 5-fluorouracil and methotrexate in patients with advanced ovarian cancer at the National Cancer Institute (NCI...
Using cell line models, we confirmed that chemotherapy agents, particularly SN-38, the active metabolite of irinotecan, stimulated the expression of stimulatory MHC class I alleles through stimulation of the TAP1 and TAP2 pathway expression. Application of ICP47, a specific TAP inhibitor, ...
1996: Optimal control problems arising in cell-cycle-specific cancer chemotherapy Cell Proliferation 29(3): 117-139 Alamir, M.; Chareyron, S. 2007: State-constrained optimal control applied to cell-cycle-specific cancer chemotherapy Optimal Control Applications and Methods 28(3): 175-190 Alamir...
This phenomenon may be attributed to generic host repair mechanism in response to chemotherapy-induced extensive tissue damage, but does not depend on the specific types of chemotherapy agents. Studies have described the increase in CSCs and EMT induced by chemotherapy treatments. However, whether the...
Alkylating agents.These drugs damage cell DNA, which is genetic material in charge of growth and development. This prevents cancer cells from multiplying. Alkylating agents are the oldest and most common type of chemotherapy. They include:
It was pointed out that “The vast majority of all agents used to directly kill cancer cells (ionizing radiation, most chemotherapeutic agents and some targeted therapies) work through either directly or indirectly generating reactive oxygen species that block key steps in the cell cycle.” The ...
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer Mutations in BRCA2 confer an increased risk of can Brough,R.,Bajrami,... - 《Embo Journal》 被引量: 58发表: 2012年 APRIN is a cell cycle...
cytotoxic agents might affect the overall reaction to chemotherapeutic treatment and determine the metastatic outcome. To ensure that our findings are not model-specific, we performed similar experiments in an additional mouse model of transplantable TNBC, using the EO771 cell line37. Mice were ...
Moreover, drug class enrichment analysis of datasets from the LINCS L1000 project37 revealed that PD-L2 is upregulated by known inducers of cellular senescence, such as DNA damage agents and cell cycle inhibitors (Extended Data Fig. 1a). Indeed, PD-L2 transcript levels were upregulated in ...