cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
Sildenafil (Sil) increases cGMP and inhibits RhoA, and this intracellular pathway has pronounced effects on NHE3 activity. The aim of this work was to determine the effects of Sildenafil on NHE3 and to study the intracellular signaling pathway involved. The studies were performed by the ...
40、n inhibits oxidative/nitrative stress during myocardial ischemia and reperfusion via PKA signaling.Am J Physiol Endocrinol Metab,Dec 2013;305:E1436-E144315 Kohler D,Straub A,Weissmuller T et al.Phosphorylation of Vasodilaor- Stimulated Phosphoprotein Prevents Platelet-Neutrophil Complex Formation an...
Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K+ channels in rat hearts. Nitric oxide (NO) plays an important role in anoxic preconditioning to protect the heart against ischemia-reperfusion injuries. The present work was perfor...
The inhibition of the nitric oxide-cGMP-PKG-JNK signaling pathway avoids the development of tolerance to the local antiallodynic effects produced by morphine during neuropathic pain. Eur J Pharmacol 2012; 685 (1-3):42-51.Hervera A, Leanez S, and Pol O (2012) The inhibition of the ...
Moreover, we found that IL-10 deletion in B cells leads to alterations in the cGMP-PKG signaling pathway. In addition, an exogenous supply of IL-10... Z Sun,A Chen,Fang, HongweiSun, DonglinHuang, MeiyingCheng, ErdengLuo, MengyuanZhang, XiaorenFang, HaoQian, Guojun - 《Cell Death & ...
Note: cGMP-PKG, cGMP-dependent protein kinase (PKG) signaling pathway; ADRA1A, adrenoceptor alpha 1A; SLC8A1, solute carrier family 8 member A1; EDNRB, Endothelin Receptor Type B; ATP1A2, ATPase Na+/K+ transporting subunit alpha 2; KCNJ8, Potassium inwardly rectifying channel subfamily J mem...
Room D, 10\\/16\\/2000 9: 00 AM - 11: 00 AM (PS) Immunohistochemical Localization of the NO-cGMP-PKG Signaling Pathway in Rat Kidney 喜欢 0 阅读量: 7 作者:Zhan,Xinhua,Li,Dechun,Johns,Roger,A.DOI: 10.1097/00000542-200009001-00623 年份: 2000 ...
Conclusions/Significance: These data indicate that the peripheral antinociceptive effects of JWH-015 during chronic inflammatory pain are mainly produced by the local activation of the nitric oxide-cGMP-PKG-KATP signaling pathway, triggered by NOS1 and mediated by endogenous opioids. These findings ...
4A–D), suggesting that melatonin might inhibit myocardial oxidative stress through cGMP-PKG signaling pathway. To directly explore this possibility, the cGMP-PKG signaling in MI/R-injured diabetic heart was determined. As summarized in Fig. 4E–H, both our western blot analysis and ...