cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
Sildenafil (Sil) increases cGMP and inhibits RhoA, and this intracellular pathway has pronounced effects on NHE3 activity. The aim of this work was to determine the effects of Sildenafil on NHE3 and to study the intracellular signaling pathway involved. The studies were performed by the ...
40、n inhibits oxidative/nitrative stress during myocardial ischemia and reperfusion via PKA signaling.Am J Physiol Endocrinol Metab,Dec 2013;305:E1436-E144315 Kohler D,Straub A,Weissmuller T et al.Phosphorylation of Vasodilaor- Stimulated Phosphoprotein Prevents Platelet-Neutrophil Complex Formation an...
Hervera A, Leanez S, and Pol O (2012) The inhibition of the nitric oxide-cGMP-PKG-JNK signaling pathway avoids the development of tolerance to the local antiallodynic effects produced by morphine during neuropathic pain. Eur J Pharmacol 685:42-51....
近年来我国心血管疾病(CCVD)位列各种疾病死因的第一位,缺血性心血管疾病(ICCVD)是临床心血管疾病的主要发病类型.心血管疾病的发病机理较复杂,目前其机制尚未完全阐明,研究表明它的发病与多种因素有关,其中缺血再灌注损伤(ischemia- reperfusion,IR)是缺血性心血管疾病主要的病理过程[1].已有研究显示,缺血再灌注过程...
【关键词】 心血管疾病;信号传导;一氧化氮;环磷酸鸟苷酸 NO-cGMP-PKGpathwayandcardiovasculardisease ZhangBinglun,Liu Chunfeng.Departmentof Pediatric Intensive Care Unit,Shengjing Hospital of ChinaMedical University,Shenyang 110004,China 【Abstract】 Nitric oxide(NO),cyclic guanosine 3′,5′-monophosphate(...
Note: cGMP-PKG, cGMP-dependent protein kinase (PKG) signaling pathway; ADRA1A, adrenoceptor alpha 1A; SLC8A1, solute carrier family 8 member A1; EDNRB, Endothelin Receptor Type B; ATP1A2, ATPase Na+/K+ transporting subunit alpha 2; KCNJ8, Potassium inwardly rectifying channel subfamily J mem...
in addition to increasing melanogenesis. PPIX functions primarily by activating the guanylate cyclase (GC) and cyclic guanosine 3', 5'-monophosphate/protein kinase G (cGMP/PKG) signaling pathways. Once activated, these pathways increase tyrosinase ...
Fig. 5: PRTG activates the downstream cGMP/PKG signaling pathway in gastric cancer cells. AExpression of top 500 genes positively associated with PRTG expression in gastric patients from TCGA database.BGene ontology term enrichment analysis for top 8 biological process controlled by differentially expr...
Conclusions/Significance: These data indicate that the peripheral antinociceptive effects of JWH-015 during chronic inflammatory pain are mainly produced by the local activation of the nitric oxide-cGMP-PKG-KATP signaling pathway, triggered by NOS1 and mediated by endogenous opioids. These findings ...