cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
This study thus suggested a novel NO/cGMP/PKG/5-HD-sensitive factor/ROS (H2O2) signaling pathway responsible for the NO/PKG-induced stimulation of pancreatic/neuronal-type KATP channels. 机译:ATP敏感性钾(KATP)通道由细胞内ATP和ADP控制,并用作代谢传感器,以将细胞的代谢状态和能量需求与细胞膜电...
Activation of cGMP-PKG signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro acute ... ZJ Huang,LI Hao-Chuan,S Liu - 《Acta Physiologica Sinica》 被引量: 13发表: 2012年 Upregulation of Sodium Channel Nav1.3 and Functional In...
NO-cGMP-PKG signaling pathway is involved in sympathetic sensitization. Keywords: sympathetic sensitization; norepinephrine; signaling pathway Part 2 The mechanisms of potassium channels underlying excitability of DRG neurons Presently, there are clear evidences that ectopic firing in injury nerve or DRG ...
内容提示: Contents lists available at ScienceDirectBBA - Molecular Basis of Diseasejournal homepage: www.elsevier.com/locate/bbadisGenes of the cGMP-PKG-Ca 2+ signaling pathway are alternatively spliced incardiomyopathy: Role of RBFOX2Xianxiu Wan a , KarryAnne Belanger b , Steven G. Widen b ...
Cardiac hypertrophy is an abnormal enlargement of heart muscle. It frequently results in congestive heart failure, which is a leading cause of human death. Previous studies demonstrated that the nitric oxide (NO), cyclic GMP (cGMP), and protein kinase G (PKG) signaling pathway can inhibit cardia...
Banxia Xiexin Decoction(半夏泻心汤) Treats Diabetic Gastroparesis through PLC-IP3-Ca2+/NO-cGMP-PKG Signal Pathway Objective:To test the effect of Banxia... 被引量: 0发表: 0年 Xiangshaliujunzi Decoction for the treatment of diabetic gastroparesis: A systematic review AIM:To assess the current...
Moreover, BBR enhanced NO and cGMP concentrations, leading to the activation of the NO/cGMP/PKG signaling via activating AKT1/MAPK axis. The in vivo experiments were consistent with the findings obtained in vitro. Hence, BBR represents a drug candidate for diabetic patients and its mechanism of...
Note: cGMP-PKG, cGMP-dependent protein kinase (PKG) signaling pathway; ADRA1A, adrenoceptor alpha 1A; SLC8A1, solute carrier family 8 member A1; EDNRB, Endothelin Receptor Type B; ATP1A2, ATPase Na+/K+ transporting subunit alpha 2; KCNJ8, Potassium inwardly rectifying channel subfamily J mem...