研究表明它的发病与多种因素有关,其中缺血再灌注损伤(ischemia- reperfusion,IR)是缺血性心血管疾病主要的病理过程[1].已有研究显示,缺血再灌注过程中,通过激活eNOS-NO系统,从而激活下游的cGMP-PKG信号通路,实现对缺血性组织的保护.本文就eNOS-NO-cGMP-PKG信号通路在心血管系统缺血再灌注损伤中的作用及研究进展作一...
已有研究显示,缺血再灌注过程中，通过激活eNOS-NO系统，从而激活下游的cGMP-PKG信号通路，实现对缺血性组织的保护。本文就eNOS-NO-cGMP-PKG信号通路在心血管系统缺血再灌注损伤中的作用及研究进展作一综述。【关键词】缺血再灌注损伤一氧化氮合酶一氧化氮蛋白激酶G 信号通路 【中图分类号】R319 【文献标识码】A...
cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
【Key words】 Cardiovascular diseases;Signal transduction;Nitric oxide;Cyclic GMP NO-cGMP-PKG通路在心脏功能的调节中发挥重 phate, cGMP) 是一种第二信使, 由鸟苷酸环化酶 要作用, 包括心力衰竭、 心肌肥大和缺血性心肌病等 (guanylate cyclase, GC ) 作用于三磷酸鸟苷 中均有NO-cGMP-PKG通路的参与。
The aim of this work was to determine the effects of Sildenafil on NHE3 and to study the intracellular signaling pathway involved. The studies were performed by the stationary microperfusion technique, in which we measured Hsecretion in rat renal proximal tubules (PT), through a H-sensitive ...
Hervera A, Leanez S, and Pol O (2012) The inhibition of the nitric oxide-cGMP-PKG-JNK signaling pathway avoids the development of tolerance to the local antiallodynic effects produced by morphine during neuropathic pain. Eur J Pharmacol 685:42-51....
multiple members of the cGMP/PKG signaling pathway were positively associated with PRTG expression. Indeed, our data demonstrate that the cGMP/PKG signaling-associated proteins, including sGC, PKG1/2 and pVASP were significantly upregulated by PRTG in gastric cancer cells. Moreover,3320,34,35,3620...
研究表明eNOS-NO-cGMP-PKG信号转导通路在缺血再灌注损伤过程中发挥了重要作用。本文就eNOS-NO-cGMP-PKG信号转导通路在缺血再灌注损伤过程中的作用及研究进展做一综述。1.缺血再灌注损伤的研究现状 1955年，Sewell结扎狗冠状动脉后，突然解除结扎，恢复血流，动物发生室颤而死亡。1960年，Jennings第一次提出心肌再灌注...
缺血再灌注时,PKG被cGMP 激活,可以磷酸化下游蛋白的Ser/Thr的羟基,从而实现对缺血再灌注损伤的保护作用。2.5 cGMP-PKG信号通路cGMP/PKG信号通路是细胞内重要的信 24、号转导通路之一,缺血再灌注造成血管内皮损伤,进而导致内皮细胞一氧化氮合成酶(eNOS)活性减弱,NO合成减少,抑制了NO-cGMP-PKG 信号通路,导致血管内皮...
We conclude that changes in gene expression may influence the Ca2+ mobilization pathway in ChD, and AS impacts the genes involved in cGMP/PKG/Ca2+ signaling pathway in ChD and diabetes. Our findings suggest that ChD patients with diabetes may be at increased risk of cardiomyopathy and heart ...