cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
3.5. VDR Regulates BNP Neurite Growth and Survival of SGNs through cGMP-PKG Signaling Pathway In the rat cochlea, we first determined the expression of BNP and VDR in the SGNs. With the culture of SG explants and single neurons, we demonstrated that BNP could promote neurite growth and surviv...