cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
This study thus suggested a novel NO/cGMP/PKG/5-HD-sensitive factor/ROS (H2O2) signaling pathway responsible for the NO/PKG-induced stimulation of pancreatic/neuronal-type KATP channels. 机译:ATP敏感性钾(KATP)通道由细胞内ATP和ADP控制,并用作代谢传感器,以将细胞的代谢状态和能量需求与细胞膜电...
Here, we provide evidence supporting the idea that CCD or ADD treatment activates cGMP-PKA signaling pathway in the DRG neurons. The results showed that CCD or ADD results in increase of levels of cGMP concentration and expression of PKG-I mRNA, as well as PKG-I protein in DRG. CCD or ...
内容提示: Contents lists available at ScienceDirectBBA - Molecular Basis of Diseasejournal homepage: www.elsevier.com/locate/bbadisGenes of the cGMP-PKG-Ca 2+ signaling pathway are alternatively spliced incardiomyopathy: Role of RBFOX2Xianxiu Wan a , KarryAnne Belanger b , Steven G. Widen b ...
Immunohistochemical localization of PDE10A in the rat brain - ScienceDirect PDE10A is a newly identified cAMP/cGMP phosphodiesterase for which mRNA is highly expressed in the mammalian striatum. In the present study, PDE10A protein... Thomas F Seeger a,Brenda Bartlett a,Timothy M Coskran b,.....
► Complex I reduced carrageenin-induced hyperalgesia and myeloperoxidase activity. ► Complex I diminished capsaicin (TRPV1 agonist)-induced nociception. ► Complex I effect depends on cGMP/PKG/ATP-sensitive potassium channel signaling.关键词: Nitric oxide donor Ru(bpy)2(NO)SO3](PF6 ...
3.5. VDR Regulates BNP Neurite Growth and Survival of SGNs through cGMP-PKG Signaling Pathway In the rat cochlea, we first determined the expression of BNP and VDR in the SGNs. With the culture of SG explants and single neurons, we demonstrated that BNP could promote neurite growth and surviv...