内容提示: Contents lists available at ScienceDirectBBA - Molecular Basis of Diseasejournal homepage: www.elsevier.com/locate/bbadisGenes of the cGMP-PKG-Ca 2+ signaling pathway are alternatively spliced incardiomyopathy: Role of RBFOX2Xianxiu Wan a , KarryAnne Belanger b , Steven G. Widen b ...
在这个过程中, cAMP/PKA信号通路对相关指标的调节是双向的, 其双向作用与对成骨细胞和破骨细胞的影响有关, 在不同的细胞或者是同一细胞的不同系中, 表现出促进或者是抑制的不同作用, 表明了该信号通路在骨形成中作用的复杂性。 3 cGMP/PKG信号通路及其调节骨形成的功能 3.1 cGMP/PKG信号通路 cGMP(环鸟苷酸...
The cGMP/PKG Signaling Pathway Underlies the Inhibitory Effect of Sildenafil Citrate on NHE3 Activity in Rat Renal Proximal TubulesSildenafil (Sil) increases cGMP and inhibits RhoA, and this intracellular pathway has pronounced effects on NHE3 activity. The aim of this work was to determine the ...
本文就eNOS-NO-cGMP-PKG信号转导通路在缺血再灌注损伤过程中的作用及研究进展做一综述。1.缺血再灌注损伤的研究现状 1955年，Sewell结扎狗冠状动脉后，突然解除结扎，恢复血流，动物发生室颤而死亡。1960年，Jennings第一次提出心肌再灌注损伤的概念；1967年，Bulkley 和Hutchins发现冠脉搭桥血管再通后的病人发生心肌细胞...
Recent studies have indicated that, following chronic compression of DRG (CCD) or acute dissociation of DRG (ADD) treatment, both hyperexcitability of neurons in intact DRG and behaviorally ex- pressed hyperalgesia are maintained by activity in cGMP-PKG signaling pathway. Here, we provide evidence ...
cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
cGMP,PKG的含量明显高于模型组,Frizzled4的含量与模型组无差异.结论:雷公藤多苷对咪喹莫特诱导银屑病样小鼠皮损组织中Wnt5a-Frizzled2/Frizzled3/Frizzled5/Frizzled... 刘秀卿,李卓成,吴文中 - 《海南医学院学报》 ...
潘等13通过结扎新西兰兔冠状动脉左前回旋支后恢复血流进行再灌注造成缺血再灌注损伤模型,采用伊文思蓝和氯化三苯基四氮唑双染色法测定心肌梗死面积,证明cGMP-PKG 信号转导通路对心肌缺血再灌注损伤产生保护作用;Lochner25等研究发现,通过预处理诱导心肌的保护作用从而对抗缺血再灌注损伤,与心肌细胞中cGMP 含量的升高有关;...
cGMP/PKG Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of CNG Channel-Deficient Mice: H. Ma, et al.; J. Biol. Chem. (2015), Application(s):ELISA using mouse retinal lysate,Abstract;Full Text ...
多个疼痛模型均证实NO是伤害性疼痛信号中的重要介质[31-34], 大量的文献已经证实NO-cGMP-PKG信号通路参与介导神经痛和炎症痛的痛 觉过敏[35],并在伤害性疼痛信号的传递过程中发挥着重要作用。另外有报道 NO-cGMP-PKG信号通路不仅有致痛作用,而且还可以产生镇痛效应[36-37]。 这可能与初级伤害性感觉神经元的亚型...