………7 四论文正文:cGMP/PKG信号通路在心肌缺血再灌注损伤的作用机制研究…12 前言………12 第一部分cGMP/PKG信号通路的激活与RISK信号通路关系………14 材料和方法………14 结果………24 讨论………29 第二部分cGMP/PKG信号通路的激活对mPTP开放和GSK-3β的影响……33 材料和方法………33 结果………...
研究表明eNOS-NO-cGMP-PKG信号转导通路在缺血再灌注损伤过程中发挥了重要作用。本文就eNOS-NO-cGMP-PKG信号转导通路在缺血再灌注损伤过程中的作用及研究进展做一综述。1.缺血再灌注损伤的研究现状 1955年，Sewell结扎狗冠状动脉后，突然解除结扎，恢复血流，动物发生室颤而死亡。1960年，Jennings第一次提出心肌再灌注...
关键词:诱发簇放电;α-DTX 敏感钾电流 Part 1 NO-cGMP-PKG signaling pathway involved in sympathetic sensitization on DRG small sized neuron on CCD model Candidate for master: Hui-ming Li Supervisor: Jun-ling Xing Department of Neuroscience, Fourth Military Medical University, Xi’an 710032, China ...
cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
内容提示: Contents lists available at ScienceDirectBBA - Molecular Basis of Diseasejournal homepage: www.elsevier.com/locate/bbadisGenes of the cGMP-PKG-Ca 2+ signaling pathway are alternatively spliced incardiomyopathy: Role of RBFOX2Xianxiu Wan a , KarryAnne Belanger b , Steven G. Widen b ...
Activation of cGMP-PKG signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro acute ... ZJ Huang,LI Hao-Chuan,S Liu - 《Acta Physiologica Sinica》 被引量: 13发表: 2012年 Upregulation of Sodium Channel Nav1.3 and Functional In...
Sildenafil (Sil) increases cGMP and inhibits RhoA, and this intracellular pathway has pronounced effects on NHE3 activity. The aim of this work was to determine the effects of Sildenafil on NHE3 and to study the intracellular signaling pathway involved. The studies were performed by the ...
This study thus suggested a novel NO/cGMP/PKG/5-HD-sensitive factor/ROS (H2O2) signaling pathway responsible for the NO/PKG-induced stimulation of pancreatic/neuronal-type KATP channels. 机译:ATP敏感性钾(KATP)通道由细胞内ATP和ADP控制,并用作代谢传感器,以将细胞的代谢状态和能量需求与细胞膜电...
Hervera A, Leanez S, Pol O: The inhibition of the nitric oxide- cGMP-PKG-JNK signaling pathway avoids the development of tolerance to the local antiallodynic effects produced by morphine during neuropathic pain. Eur J Pharmacol 2012; 685:42-51...