Conclusion LFG exhibited the lipid-lowering effect, which might be attributed to downregulating ADRB2 and NOS3, and upregulating LDLR through the cGMP-PKG signaling pathway in hyperlipidemia rat. Ferulic acid and p-hydroxybenzoic acid might be the underlying active ingredients which affect the ...
pathway Abstract Object:To observe whether the myocardial protective effect of BNP which activate the cGMP/PKG signaling pathway is associated with the activation of and ERK1/2 protein kinase. Methods: 84 New Zealandwhite rabbits were randomly divided into seven ...
Cardiac hypertrophy is an abnormal enlargement of heart muscle. It frequently results in congestive heart failure, which is a leading cause of human death. Previous studies demonstrated that the nitric oxide (NO), cyclic GMP (cGMP), and protein kinase G (PKG) signaling pathway can inhibit cardia...
关键词:诱发簇放电;α-DTX 敏感钾电流 Part 1 NO-cGMP-PKG signaling pathway involved in sympathetic sensitization on DRG small sized neuron on CCD model Candidate for master: Hui-ming Li Supervisor: Jun-ling Xing Department of Neuroscience, Fourth Military Medical University, Xi’an 710032, China ...
Activation of cGMP - PKG signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro aeute ... ZJ Huang,LI Hao-Chuan,S Liu - 《Acta Physiologica Sinica》 被引量: 13发表: 2012年 Upregulation of Sodium Channel Nav1.3 and Functional...
内容提示: Contents lists available at ScienceDirectBBA - Molecular Basis of Diseasejournal homepage: www.elsevier.com/locate/bbadisGenes of the cGMP-PKG-Ca 2+ signaling pathway are alternatively spliced incardiomyopathy: Role of RBFOX2Xianxiu Wan a , KarryAnne Belanger b , Steven G. Widen b ...
Note: cGMP-PKG, cGMP-dependent protein kinase (PKG) signaling pathway; ADRA1A, adrenoceptor alpha 1A; SLC8A1, solute carrier family 8 member A1; EDNRB, Endothelin Receptor Type B; ATP1A2, ATPase Na+/K+ transporting subunit alpha 2; KCNJ8, Potassium inwardly rectifying channel subfamily J mem...
Next, we further probed the potential signaling pathway underlying the effects of empagliflozin on cardiomyocytes. It is widely recognized that sGC-cGMP-PKG pathway serves as a common mediator of cardioprotection and the impairment of this signaling and low cGMP levels are conspicuous traits arising in...
This study thus suggests that PKG exerts dual regulation of neuronal KATP channels, and the NO/soluble guanylyl cyclase (sGC)/cGMP/PKG signaling pathway positively modulates the function of neuronal/pancreatic-type KATP channels.;In the second part of the project, I further explored the signaling ...
40、n inhibits oxidative/nitrative stress during myocardial ischemia and reperfusion via PKA signaling.Am J Physiol Endocrinol Metab,Dec 2013;305:E1436-E144315 Kohler D,Straub A,Weissmuller T et al.Phosphorylation of Vasodilaor- Stimulated Phosphoprotein Prevents Platelet-Neutrophil Complex Formation an...