cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
CONCLUSION: DNP inhibits IK(V) in a NP-cGMP-PKG pathway-dependent and cAMP/PKA pathway-independent manner. IK(V) may play a critical role in regulating resting mem-brane potential in the gastric antral circular myocytes of guinea pigs. Key Words: Dendroaspis natriuretic peptide; De-layed ...
Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation. Am J Physiol Gastrointest Liver Physiol. 2006;290:G535-G542.Perri RE, Langer DA, Chatterjee S, Gibbons SJ, Gadgil J, Cao S, Farrugia G, Shah VH. Defects in cGMP-PKG ...
近年来我国心血管疾病(CCVD)位列各种疾病死因的第一位,缺血性心血管疾病(ICCVD)是临床心血管疾病的主要发病类型.心血管疾病的发病机理较复杂,目前其机制尚未完全阐明,研究表明它的发病与多种因素有关,其中缺血再灌注损伤(ischemia- reperfusion,IR)是缺血性心血管疾病主要的病理过程[1].已有研究显示,缺血再灌注过程...
通路(Pathway) Anti-infection CAS号(CAS NO.) 188343-77-3 分子式(Formula) C21H22FN3 分子量(Molecular Weight) 335.42 纯度(Purity) ≥98% 结构式(Structure) 运输和保存方法 粉末-25~-15℃保存,有效期3年;溶于溶剂,-85~-65℃保存,有效期2年 ...
NO-cGMP-PKG pathway and cardiovascular disease 引用 收藏 分享 摘要 一氧化氮( NO)、环磷酸鸟苷酸( cGMP)、环磷酸鸟苷酸依赖的蛋白激酶( PKG)在多种组织细胞中发挥重要的生物功能。基于NO-cGMP-PKG途径与心血管疾病的紧密联系。该文对近期与NO-cGMP-PKG通路、心血...展开更多 Nitric oxide ( NO ) , ...
该文对近期与 NO-cGMP-PKG 通路、心血管疾病等相关的文献进行检索与回顾,总结 NO-cGMP-PKG 信号通路的生物作用及其与心血管疾病的关系,旨在为心血管疾病发生机制的研究提供一个新思路。【关键词】 心血管疾病;信号传导;一氧化氮;环磷酸鸟苷酸NO-cGMP-PKG pathway and cardiovascular disease......
43、T. Life history of ENOS: partnes and pathwayJ. Cardiovasc Res, 2007, 75(2:24726020于娜,孙小燕.内皮型一氧化氮合酶对缺血再灌注组织微循环的影响.微循环学杂志. 2013 23(3:656721 Kao RL,Martin CM,Xenocostas A,et al.Erythropoietin improves skeletal muscle microcirculation through the activation...
The activation of JNK and ERK1/2 by insulin was attenuated by BK, which was mediated by the sGC-cGMP-PKG pathway. While insulin-stimulated phosphorylation of upstream activators of JNK and ERK, i.e., MKK4 and MEK1/2, was unaffected, BK augmented insulin-mediated induction of MKP-5 mRNA...
【关键词】 心血管疾病;信号传导;一氧化氮;环磷酸鸟苷酸 NO-cGMP-PKGpathwayandcardiovasculardisease ZhangBinglun,Liu Chunfeng.Departmentof Pediatric Intensive Care Unit,Shengjing Hospital of ChinaMedical University,Shenyang 110004,China 【Abstract】 Nitric oxide(NO),cyclic guanosine 3′,5′-monophosphate(...