The importance of cyclic nucleotides and especially the NO-cGMP-PKG pathway as potent inhibitors of platelet activation has been well established by many investigators in human and animal platelets. However, recently a new mechanism of platelet activation by vWF, mediated by PKG (that sequentially ...
Cardiac hypertrophy is an abnormal enlargement of heart muscle. It frequently results in congestive heart failure, which is a leading cause of human death. Previous studies demonstrated that the nitric oxide (NO), cyclic GMP (cGMP), and protein kinase G (PKG) signaling pathway can inhibit cardia...
该文对近期与 NO-cGMP-PKG 通路、心血管疾病等相关的文献进行检索与回顾,总结 NO-cGMP-PKG 信号通路的生物作用及其与心血管疾病的关系,旨在为心血管疾病发生机制的研究提供一个新思路。【关键词】 心血管疾病;信号传导;一氧化氮;环磷酸鸟苷酸NO-cGMP-PKG pathway and cardiovascular disease... ...
GMP/PKG signaling pathway and the RISK signaling pathway Abstract Object:To observe whether the myocardial protective effect of BNP which activate the cGMP/PKG signaling pathway is associated with the activation of and ERK1/2 protein kinase. ...
Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves. J Physiol 574: 167-181, 2006.Sergeant GP, Johnston L, McHale NG, Thornbury KD, Hollywood MA. Activation of the cGMP/PKG pathway ...
To further explore the potential molecular mechanism regarding protective action of empagliflozin in vivo, the activity of sGC-cGMP-PKG pathway were examined. According to Western blot analysis or immunohistochemistry results, p-eNOS/t-eNOS and sGC-β expression presented a significant decrease in diabe...
心血管疾病的发病机理较复杂，目前其机制尚未完全阐明，研究表明它的发病与多种因素有关，其中缺血再灌注损伤（ischemia-reperfusion，IR）是缺血性心血管疾病主要的病理过程[1]。已有研究显示,缺血再灌注过程中，通过激活eNOS-NO系统，从而激活下游的cGMP-PKG信号通路，实现对缺血性组织的保护。本文就eNOS-NO-cGMP-PKG...
Activation of the cGMP-PKG pathway has demonstrated inhibitory effects on proliferation, migration, and invasion of PCa cells [3,4]. Additionally, our research focuses on B-type endothelin receptor (EDNRB). The EDNRB gene, located on chromosome 13 q22 with GenBank ID 1910, spans approximately ...
背根节慢性压迫模型小细胞交感敏化的no-cgmp-pkg信号通路分析-no - cgmp - pkg signal pathway analysis of sympathetic sensitization of small cells in chronic dorsal root ganglion compression model.docx,第四军医大学硕士学位论文 第四军医大学硕士学位论文 HYPERLI
3.5. VDR Regulates BNP Neurite Growth and Survival of SGNs through cGMP-PKG Signaling Pathway In the rat cochlea, we first determined the expression of BNP and VDR in the SGNs. With the culture of SG explants and single neurons, we demonstrated that BNP could promote neurite growth and surviv...