为进一步揭示STING 运输过程中在各个细胞器的调控因子,并深入探讨cGAS/cGAMP非依赖型STING 激活的过程以及其在神经炎症发病机制中的功能,2021年7月21日,德克萨斯大学西南医学中心闫楠(Dr. Nan Yan)团队(第一作者为褚婷婷博士)在Nature杂志...
cGAS-STING-IRF3通路是近年来发现的与自噬密切相关的信号通路。自噬是一种细胞自我降解的过程，对于维持细胞稳态和应对应激条件具有重要意义。探讨棕榈酸是否通过该通路影响心肌细胞的自噬功能，有助于揭示心血管疾病中自噬调控的新机制。研究目的与假设 研究目的 本研究旨在探讨棕榈酸对心肌细胞自噬功能的影响及其与cGAS-...
α-SMA)表达呈正相关.IRF3在肾脏纤维化过程中与YAP表达呈正相关.2,敲低STING可以抑制马兜铃酸诱导的HK-2细胞细胞外基质分泌并减轻炎症,同时抑制了YAP/TEAD转录靶基因的升高.敲低IRF3可以抑制马兜铃酸诱导的HK-2细胞细胞外基质分泌并减轻炎症,同时抑制了YAP/TEAD转录靶基因的升高.敲低IRF3可以挽救STING激动剂诱导的...
α-SMA)表达呈正相关.IRF3在肾脏纤维化过程中与YAP表达呈正相关.2,敲低STING可以抑制马兜铃酸诱导的HK-2细胞细胞外基质分泌并减轻炎症,同时抑制了YAP/TEAD转录靶基因的升高.敲低IRF3可以抑制马兜铃酸诱导的HK-2细胞细胞外基质分泌并减轻炎症,同时抑制了YAP/TEAD转录靶基因的升高.敲低IRF3可以挽救STING激动剂诱导的...
结果经不同浓度PA作用24 h后,NRCMs中PINK1,Parkin,LC3Ⅱ/LC3Ⅰ和LC3Ⅱ/LC3Ⅰ+Ⅱ蛋白表达量明显降低(P<0.05),p62蛋白表达量明显增高(P<0.05),且心肌细胞活性明显下降(P<0.05).将cGAS敲降后,可明显逆转PA诱导的NRCMs自噬功能降低,并改善心肌细胞活性(P<0.05).结论PA通过介导cGAS-STING-IRF3通路激活,抑制心肌...
Chromosomal instability (CIN) in cancer cells has been reported to activate the cGAS–STING innate immunity pathway via micronuclei formation, thus affecting tumor immunity and tumor progression. However, adverse effects of the cGAS/STING pathway as they
cGAS-STING-IRF3心肌细胞自噬目的探究棕榈酸(PA)对心肌细胞自噬功能的影响及潜在机制.方法提取大鼠乳鼠心肌细胞(NRCMs)并体外培养24 h,分别加入10%BSA以及不同浓度的PA(0,0.1,0.3,0.5,0.7 mmol/L)共培养24 h.Western blotting检测NRCMs中自噬指标(PINK1,Parkin,p62,LC3Ⅱ/LC3Ⅰ)以及cGAS,STING,p-IRF3/IRF3的...
Accordingly, IRF3 global knockout or conditional deletion in HSCs aggravated liver fibrosis, a process mitigated by the CDK4/6 inhibitor. These findings underscore a straightforward yet vital mechanism of cGAS-STING signaling in inducing cellular senescence and unveil its unexpected biology in limiting ...
IRF3通路有关.结论 WEE1靶向治疗联合放疗能够抑制肿瘤微环境,有效缓解放疗抵抗.WEE1抑制剂和放射治疗联合应用比单独放疗明显抑制了肿瘤的生长,联合治疗对肿瘤达到了明显的抑制效应.联合应用WEE1抑制剂和放射治疗有助于下调肿瘤微环境内的免疫抑制淋巴细胞.WEE1抑制剂联合放疗通过cGAS/STING-STAT3-IRF3途径影响肿瘤微环境...
cGAS-STING-TBK1-IRF3/7 induced interferon-beta contributes to the clearing of non tuberculous mycobacterial infection in mice cGAS-STING-TBK1-IRF3/7 induced interferon-β contributes to the clearing of non tuberculous mycobacterial infection in mice, Virulence. 2017 Apr 19:1-13... Ruangkiattikul,...