associated with Mendelian vascular (COL4A2, LOX, EPHB4, STN1) or eye (VCAN, ADAMTSL4, CRB1) disease. One might expect these proteins to instead be involved in the core vascular processes underlying small vessel disease. Notably, four of these (COL4A2, LOX, VCAN, ADAMTSL4)are key ...
FDa = arteriolar fractal dimension; VRF = vascular risk factor; WMH = white matter hyperintensities; SVD = small vessel disease. Dashed lines represent non-significant associations. Full size image We tested additional SEMs—to test for co-association of retinal and SVD ...
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the LACunar Intervention Trial-2 (LACI-2) (ISRCTN14911850). medRxiv. 2022.05.31.22275743. doi:10.1101/2022.05.31.22275743Google Scholar 12. Bath...
The clinical diagnosis of vas- cular dementia (VaD) was made by the appearance of the following features: lacunae, multiple, cystic or border- zone infarcts, microinfarcts and small vessel disease, and could be pathologically confirmed as Braak stage ≤ IV [26, 28]. Cases were classified...
Small GTPases, 5 (2014), Article e28003, 10.4161/sgtp.28003 View in ScopusGoogle Scholar 32 M.D. Sweeney, A.P. Sagare, B.V. Zlokovic Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Nat. Rev. Neurol., 14 (2018), pp. 133-150, 10.1038/nrneurol....
Delta OD 450 and Doppler velocimetry of the middle cerebral artery peak velocity in the evaluation for fetal alloimmune hemolytic disease. Which is best? Am J Obstet Gynecol. 1997;176:S18. Article Google Scholar Nishie EN, Brizot ML, Liao AW, et al. A comparison between middle cerebral ...
Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). However, studies remain limited to older cohorts wherein pathologies of both dementia (e.g. amyloid) and SVD (e.g. white matter hyperintensities) al
2 and A Rostagno*,1 Vascular deposition of amyloid-b (Ab) in sporadic and familial Alzheimer's disease, through poorly understood molecular mechanisms, leads to focal ischemia, alterations in cerebral blood flow, and cerebral micro-/macro-hemorrhages, significantly contributing to cognitive impairment...
(a–d) In vivo leakage experiments show only small-molecular-weight tracers leaked from brain microvessels in Mekk3 iKO and iEC À / À neonatal mice. (a) Sulfo-NHS-biotin (556.6 dalton) was injected into the hearts of the tamoxifen-treated Mekk3 NCL or Mekk3 iKO neonatal pups. ...
[66], indicating that stress, inflammation, and cardiovascular disease share overlapping pathomechanisms. In the present work, we show exacerbated NFkB-NLRP3-TXNIP-IL-6 signaling in the brain of DTX-treated mice, which, however, was not translated to the peripheral vasculature as inflammation and...