Cerebral small vessel disease (cSVD) is a prevalent condition in aging that affects the brain's small arteries, arterioles, venules, and capillaries. It often manifests as abnormalities on brain imaging, such as white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), or ...
Whether white matter lesion (WML) is associated with vascular cognitive impairment in cerebral small vessel disease (CSVD) remains controversial; some severe CSVD patients retain normal cognitive function, and cortical thinning associated with WMLs has also been recently reported. The contribution of cort...
Homocys- teine and cerebral small vessel disease in patients with symptomatic athero- sclerotic disease. The SMART-MR study. Atherosclerosis 2011;216:461–6. 51. Stuart S, Cox HC, Lea RA, Griffiths LR. The role of the MTHFR gene in migraine. Headache 2012;52:515–20. 52. Dodelson de...
The Positional Relationship between Lacunae and White Matter Hyperintensity in Patients with Cerebral Small Vessel Disease Background: Lacunae and white matter hyperintensity (WMH) are two crucial imaging biomarkers of cerebral small vessel disease (CSVD). Multiple studies have... L An,W Yuan,Wang, ...
ACTA2 Cerebral Arteriopathy: Not Just a Puff of Smoke 2018, Cerebrovascular Diseases Vascular disease-causing mutation, smooth muscle α-actin R258C, dominantly suppresses functions of α-actin in human patient fibroblasts 2017, Proceedings of the National Academy of Sciences of the United States of...
Frequency not reported: Constipation, difficulty swallowing, dry mouth, dysphagia, gastroesophageal reflux disease (GERD/GORD), tongue protrusion Postmarketing reports: HiccupsAripiprazole Extended/Prolonged-Release IM Suspension: Very common (10% or more): Constipation (up to 10%) Common (1% to 10%...
Frequency not reported: Constipation, difficulty swallowing, dry mouth, dysphagia, gastroesophageal reflux disease (GERD/GORD), tongue protrusion Postmarketing reports: HiccupsAripiprazole Extended/Prolonged-Release IM Suspension: Very common (10% or more): Constipation (up to 10%) Common (1% to 10%...
Introduction: Estimation of impaired cerebral vascular reserve by means of TCD in patients with severe carotid disease can be achieved by the assessment of cerebral blood flow changes in response to various vasodilatatory stimuli. In patients with high-grade stenosis or occlusion of the ICA significa...
Hemorrhage/hemorrhagic events included all hemorrhage terms (including anal hemorrhage, ruptured aneurysm, blood blister, blood loss anemia, blood urine present, catheter site hematoma, cerebral hemorrhage, cerebral microhemorrhage, conjunctival hemorrhage, contusion, hemorrhagic diarrhea, disseminated ...
GPA typically affects the upper respiratory tract, lungs and kidneys, but all organs can be involved because the disease is a systemic form of granulomatous small-vessel vasculitis. The central nervous system (CNS), particularly the pituitary, is rarely involved [1]. Until 2016, only 2 cases ...