Cerebral small vessel diseaseNeuroimagingPathobiologyRisk factorsThe cerebral microvasculature is exceptionally vulnerable to changes due to aging. Both the radiological and clinical manifestations of cerebral
Cerebrovascular diseasecommonly occurs in cancer patients, often from mechanisms and processes specific tomalignancy. Stroke may arise by direct tumor effects, through restriction of cerebral blood flow from tumor-associated mass effect and edema, direct blood vessel infiltration, or intratumoral hemorrhage...
Brain infarction due to small vessel cerebrovascular disease (SVCD)—also known as small vessel infarct (SVI) or “lacunar” stroke—accounts for 20% to 25% of all ischemic strokes. Historically, SVIs ha...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a type of hereditary small-vessel disease. Our research showed a positive correlation between the grade of retinal arteriole stenosis and the extent of white matter hyperin-tensities in CADASIL. In ...
Parkinson’s disease (PD) and cardio-cerebrovascular diseases are related, according to earlier studies, but these studies have some controversy. Our aim was to assess the impact of PD on cardiocerebrovascular diseases using a Mendelian randomization (MR) method. The data for PD were single nucleo...
Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovasc Res. 2018;114:1462–73. Article CAS PubMed PubMed Central Google Scholar McCullough LD, Moro MA. Translational interdisciplinary science-immune cell niches: possible targets for stroke therapy? Stroke. 2021...
cerebral small vessel disease (csvd) is a common disease in the elderly, and its pathogenesis is still being explored. glymphatic clearance function can be evaluated by diffusion tensor imaging analysis along the perivascular space (dti-alps) index. this study aims to investigate the changes in ...
Cerebrovascular disease often involves small vessel disease (SVD), where complete or incomplete small subcortical lesions are associated with cognitive impairment, mood disturbances, and dementia. SVD is also the most common form of cerebrovascular pathology found in asymptomatic patients by brain imaging....
RCT: Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease View LargeDownload Figure 1. Study Flow Diagram View LargeDownload ISMN indicates isosorbide mononitrate. Figure 2. Cognition at 12 Months Assessed Using 7-Level Ordinal Adjusted Analysis View...
‘small vessel disease’ in AD but most have conflated parenchymal ischaemic lesions—particularly in the white matter—with structural disease of cerebral blood vessels.APOEgenotype influences the likelihood of ischaemic changes in AD. Morgen et al. [109] found that AD carriers of theAPOEϵ4 ...