Animal and tissue culture models have been developed over the last years shedding more light on this novel field of cancer treatment. Whether senescence induction is an advantage or a backdrop for tumour treatment has still to be elucidated since experimental proof in human tumour models is still...
B. Noncell-Autonomous Regulation of Senescence in Cancer: Role of SASP SASP对于肿瘤的形成来讲是一把双刃剑 senescent cells can induce paracrine senescence in neighboring cells, thus acting as a barrier against tumor growth.;SASP can activate immune surveillance and bring innate and adaptive immune ...
“therapy-induced senescence” (TIS) :Treatment with DNA damage agents such as UV,-irradiation , tertbutyl hydroperoxide or anticancer chemo- therapy agents activation of oncogenes[oncogene-induced senescence (OIS)] and loss of TSGs inflammaging D. Autocrine and Paracrine Senescence and Its Impac...
In the current review, we discuss the molecular regulation of cellular senescence, the potential implications of senescence in human cancers, and the possibility of exploiting cellular senescence for the treatment of cancers. Keywords: senescence; oncogenesis; cancer therapy; cell survival; cell death ...
Animal and tissue culture models have been developed over the last years shedding more light on this novel field of cancer treatment. Whether senescence induction is an advantage or a backdrop for tumour treatment has still to be elucidated since experimental proof in human tumour models is still...
Cellular senescence: when bad things happen to good cells. Nature Rev. Mol. Cell Biol. 8, 729–740 (2007). Article CAS Google Scholar Collado, M., Blasco, M. A. & Serrano, M. Cellular senescence in cancer and aging. Cell 130, 223–233 (2007). Article CAS PubMed Google Scholar ...
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prost...
First, we screened for an extrinsic signal that can induce cellular senescence in human lung adenocarcinoma cell line A549, and identified transforming growth factor- (TGF-) as the cellular senescence-inducing factor. Cancer cells senesced by treatment with TGF- impaired tumorigenicity both in vitro...
The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment Recently, more than 30 small molecules and eight monoclonal antibodies that modulate kinase signaling have been approved for the treatment of several patho... L Chang,B Juhwa,SY Han - 《Molecules》 被引量: 3发表...
Cellular senescence and cancer. The proliferative lifespan of normal mammalian cells is limited by intrinsic controls, which desensitize the cell-cycle machinery to extrinsic stimulation ... D Wynford‐Thomas - 《Journal of Pathology》 被引量: 320发表: 2015年 The ciliary pocket: an endocytic membr...