L. New horizons: novel approaches to enhance healthspan through targeting cellular senescence and related aging mechanisms. J. Clin. Endocrinol. Metab. 106, e1481–e1487 (2021). Article PubMed Google Scholar Robbins, P. D. et al. Senolytic drugs: reducing senescent cell viability to extend ...
The review aims to summarize and discuss the current knowledge on targeting senescent cells to reduce the risk of age-related diseases in animal models and... V Boccardi,P Mecocci - 《Mechanisms of Ageing & Development》 被引量: 0发表: 2021年 Cellular senescence, ageing and disease and the...
Senescence is a unique state of growth arrest that develops in response to a plethora of cellular stresses, including replicative exhaustion, oxidative injury, and genotoxic insults. Senescence has been implicated in the pathogenesis of multiple aging-related pathologies, including cancer. In cancer, ...
Targeting cellular senescence Cellular senescence refers to a state in which the cell cycle is irreversibly arrested99,100. In cartilage, oxidative stress associated with aging and mechanical overload mainly cause the accumulation of senescent chondrocytes22. Senescent chondrocytes trigger the formation of...
When senescent cells come into contact with non-senescent cells, they trigger DNA damage and senescence in contacted Therapeutic strategies targeting secondary senescent cells As briefly noted above, one key line of evidence supporting the causal role of senescent cells in aging phenotypes, age-related...
Targeting the tumor immune microenvironment Nano-drugs regulating TME are designed to relieve the immunosuppression in TME and enhance the infiltration and activation of effecting immune cells, thus improving the effect of immunotherapy [202]. PD-L1/Toll-like receptors (TLR) 7 dual-targeting nanobody...
The p38 mitogen-activated protein kinase (p38-MAPK) is a crucial signaling pathway closely involved in several physiological and cellular functions, includ... P Ganguly,T Macleod,C Wong,... - 《Pharmaceuticals》 被引量: 0发表: 2023年 Targeting cell signalling pathways to fight the flu: towards...
targeting three genes in primary human T cells with the frequency of editing up to 45% in this trial [53]. KO efficiency could reach 85% to 98% in activated human T cells [42] and > 80% in other leukocytes [210]. CRISPR/cas9 system has been delivered with viral vectors such as...
et al. Targeting cellular senescence prevents age-related bone loss in mice. Nat. Med. 23, 1072–1079 (2017). CAS PubMed PubMed Central Google Scholar Xu, M. et al. Senolytics improve physical function and increase lifespan in old age. Nat. Med. 24, 1246–1256 (2018). CAS PubMed...
For bone-targeted therapeutic agents, in addition to improvements of the classic denosumab, romosozumab, and PTH1R ligands, potential regulation of the remodeling process targeting other key membrane expressions, cellular crosstalk, and gene expression, of all bone cells has been exploited. For bone...