Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med 2002; 195: 1533–1539. Article CAS PubMed PubMed Central Google Scholar Klebanoff CA, Finkelstein SE, Surman DR, Lichtman MK, Gattinoni L, Theoret MR et al. IL-15 ...
An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis. Virology 295 : 272-283.S. Girard, P. Shalhoub, P. Lescure et al., "An altered cellular response to interferon and up-regulation of ...
Based on previous reports39,40, genes related to pattern recognition receptors, antimicrobial peptides, complement molecules, lectin family members, cytokines in innate immunity, interleukin-1 family members and receptors, tumor necrosis factor, chemokines, and the major histocompatibility complex were ...
The mechanisms by which chronic hepatitis B is completely resolved through antiviral therapy are unknown, and the contribution of acquired T cell immunity to hepatitis B surface antigen (HBsAg) seroclearance has not been investigated. Therefore, we measu
cells, with a counter-screen against proliferation of ERα-negative MDA-MB231 breast cancer cells, mRNA levels of the proliferative genes GREB1 and MYC, and modulation of tumor necrosis factor alpha (TNF-α)-induced secretion of the inflammatory cytokine, interleukin-6 (IL-6), in MCF-7 ...
KCs are considered to be the most important type of immune cells associated with liver regeneration. During the interaction between KCs and hepatocytes, the cytokines secreted by KCs, such as tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), transform hepatocytes from the resting ...
For example, pathfinder cells according to the present invention reduce the expression or activity of IL-4, IL-6 and/or IL-10, while MSCs increase the expression or activity of IL-4, IL-6 and IL-10. Other distinctions are shown in Table 7. This discovery further confirms that path...
Key elements of the SASP are the proinflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1(IL-1)「 IL-1is considered one of the master regulators of the SASP 」 in OIS: chemokines binding to the IL-8 receptor C-X-C motif chemokine receptor 2...
PDC were stimulated with combinations of microbial- and host-derived signals, which coexist at sites of infection: interleukin (IL)-3 and influenza virus (Flu) (Toll-Like Receptor-7 ligand), GM-CSF (Granulocyte-Monocyte Colony Stimulating Factor) and Flu, and GM-CSF and antimicrobial peptide ...
Accumulation of senescent cells can cause significant tissue dysfunction. The detrimental effects of senescent cells are in part due to SASP factors. The SASP can include pro-inflammatory cytokines, such as Tumor Necrosis Factor-α (TNF-α), viral FK506-Binding Protein (vFKBP), and interleukin-...