Interleukin-4Burn injuryInjury inflicted to the body by an external force白细胞介素4BACKGROUND: Previous studies from this laboratory showed that the suppression of cell-mediated immunity after the combined injury of ethanol exposure and burn is mediated by increased presence of the proinflammatory ...
Key elements of the SASP are the proinflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1(IL-1)「 IL-1is considered one of the master regulators of the SASP 」 in OIS: chemokines binding to the IL-8 receptor C-X-C motif chemokine receptor 2...
Based on previous reports39,40, genes related to pattern recognition receptors, antimicrobial peptides, complement molecules, lectin family members, cytokines in innate immunity, interleukin-1 family members and receptors, tumor necrosis factor, chemokines, and the major histocompatibility complex were ...
(CMV) demonstrate three qualitatively different CD4 T-cell antiviral responses: (1) an IFN-γ predominant response associated with high viremia and poor immune control; (2) an IFN-γ and interleukin-2 (IL-2) response associated with low-level viremia; and (3) an IL-2 predominant response ...
cells, with a counter-screen against proliferation of ERα-negative MDA-MB231 breast cancer cells, mRNA levels of the proliferative genes GREB1 and MYC, and modulation of tumor necrosis factor alpha (TNF-α)-induced secretion of the inflammatory cytokine, interleukin-6 (IL-6), in MCF-7 ...
Profibrotic role for interleukin-4 in cardiac remodeling and dysfunction. Hypertension 66, 582–589 (2015). Article CAS PubMed Google Scholar Leask, A. Getting to the heart of the matter: new insights into cardiac fibrosis. Circ. Res. 116, 1269–1276 (2015). Article CAS PubMed Google ...
The mechanisms by which chronic hepatitis B is completely resolved through antiviral therapy are unknown, and the contribution of acquired T cell immunity to hepatitis B surface antigen (HBsAg) seroclearance has not been investigated. Therefore, we measu
a population of cells, or extracellular secretomes thereof, to an individual suffering from a disease, disorder or condition characterized by inflammation of one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce an anti-inflammatory response.Inventor...
Neutrophils are a pivotal component in the immune response that not only recruit, activate, and program antigen-presenting cells (APCs), but also produce tumor-necrosis factor (TNF) and other cytokines such as interleukin (IL)-1α, IL-1β, and IL-6 to stimulate the differentiation and ...
(vFKBP), and interleukin- (IL-) 6, chemokines, and extracellular matrix proteases, as well as bioactive lipids (bradykines, ceramides, prostenoids), micro-RNA's (miRNAs), other non-coding nucleotides, and extracellular vesicles that induce spread of senescence to non-senescent cells, tissue ...