US5932537 * Jun 7, 1995 Aug 3, 1999 Chiron Corporation Method for attenuating a cellular response to IL-1US5932537 * 1995年6月7日 1999年8月3日 Chiron Corporation Contacting a mammalian cell that is responsive to interleukin-1 with an intracellular interleukin-1 receptor antagonist (?icil-1ra...
Key elements of the SASP are the proinflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1(IL-1)「 IL-1is considered one of the master regulators of the SASP 」 in OIS: chemokines binding to the IL-8 receptor C-X-C motif chemokine receptor 2...
Based on previous reports39,40, genes related to pattern recognition receptors, antimicrobial peptides, complement molecules, lectin family members, cytokines in innate immunity, interleukin-1 family members and receptors, tumor necrosis factor, chemokines, and the major histocompatibility complex were ...
A number of mRNA expressions of interleukin-12 and interferon (IFN)-as immune cell activating cytokines, perforin and granulysin as cytotoxic factors, and myxovirus resistance protein (MX)-1 and MX-2 as anti-virus factors of PBMC were analyzed after culturing cells with phytohemagglutinin (PHA)...
Alternatively activated “anti-inflammatory” (M2) macrophages differentiate in response to interleukin (IL)-4 or IL-13 and are characterized by increased mitochondrial respiration, anti-inflammatory cytokine production, and high arginase-1 expression [18,49,50] (Fig.1A). M2 macrophages promote T he...
Key elements of the SASP are the proinflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1(IL-1)「 IL-1is considered one of the master regulators of the SASP 」 in OIS: chemokines binding to the IL-8 receptor C-X-C motif chemokine receptor 2...
The mechanisms by which chronic hepatitis B is completely resolved through antiviral therapy are unknown, and the contribution of acquired T cell immunity to hepatitis B surface antigen (HBsAg) seroclearance has not been investigated. Therefore, we measu
cells, with a counter-screen against proliferation of ERα-negative MDA-MB231 breast cancer cells, mRNA levels of the proliferative genes GREB1 and MYC, and modulation of tumor necrosis factor alpha (TNF-α)-induced secretion of the inflammatory cytokine, interleukin-6 (IL-6), in MCF-7 ...
(vFKBP), and interleukin- (IL-) 6, chemokines, and extracellular matrix proteases, as well as bioactive lipids (bradykines, ceramides, prostenoids), micro-RNA's (miRNAs), other non-coding nucleotides, and extracellular vesicles that induce spread of senescence to non-senescent cells, tissue ...
Some of them have been found to be activated under hypoxic conditions but not by the inhibition of mitochondrial respiration: this is the case for AP-1 [71], nuclear factor-interleukin-6 (NF-IL-6) [36], NF-κB-like [37], [39], [72] and Egr-1 [73] (see Faller et al. for a...