Summary In a variety of biological systems, the cellular response to an extracellular stimulus is mediated by a complex cascade of biochemical signals transduced from the cellular membrane to the specific part(s) of the cell where the response(s) occur(s). The signal transduction pathways do ...
(c) Tabular view of example profiles belonging to each of the 82 interaction profiles. The heights of the bars in each graph represent the expression levels of the four conditions (from left to right): No stimulus, X, Y and X+Y. The red line corresponds to the height of X+Y if the...
where responding T cells were also deficient in function (see below)62, although the nature or strength of the antigenic stimulus could also be relevant. It will be interesting to determine whether different CTL functional phenotypes are associated...
In the following studies, we examine cellular responses to dynamic stimuli using micropatterning and microfabrication approaches that enable greater spatiotemporal control over the stimulus. Specifically, we investigate how the controlled presentation of new extracellular matrix and growth factors regulates ...
Extracellular vesicles (EVs) have various advantageous properties, including a small size, high biocompatibility, efficient cargo loading, and precise cell
Effector kinases linking extracellular signals to cellular response under stress conditions are often referred to asstress kinasesand comprise many of the well-studied Ser/Thr kinases, such as p38 MAPK, JNK (c-Jun-N-terminal kinase), IKK (IκB kinase), PKR (double-stranded RNA-dependent kinase...
involved in stimulus-transcription coupling and mediation of extracellular signals to long-term changes in cellular phenotype, c-fos became the most widely us... Krisztina,J,Kovács - 《Neurochemistry International》 被引量: 868发表: 1998年 Cellular expression of the immediate early transcription facto...
this kind of interactions only reflects all possible static connections without stimulus-specific response or temporal changes. The interaction model includes the gene expression patterns from different time course to infer the dynamic PPIs and networks, suggesting a more significant and...
Cells typically respond to chemical or physical perturbations via complex signaling cascades which can simultaneously affect multiple physiological parameters, such as membrane voltage, calcium, pH, and redox potential. Protein-based fluorescent sensors
Extracellular Vesicles from Leishmania (Leishmania) infantum Contribute in Stimulating Immune Response and Immunosuppression in Hosts with Visceral Leishma... infantum (Leish-EVs) in recognition of the humoral and cellular immune response of hosts with VL. Promastigotes were cultivated in 199 medium and...